乳胶增强免疫比浊法在PG1、PG2临床检测中的应用价值

Value of Latex-enhanced Immunoturbidimetry in the Clinical Detection of PG1,PG2

目的:探究乳胶增强免疫比浊法在PG1、PG2临床检测中的应用价值。方法:选取2012年5月-2014年5月本院治疗的胃癌患者50例(胃癌组),同期根据病理学检查结果选择75例萎缩性胃炎患者(对照1组),50例消化性溃疡患者(对照2组),以及正常体检者50例(对照3组)。应用乳胶增强免疫比浊法检测四组患者空腹血清PG1、PG2水平,并进行对比分析。结果:对照3组的PG1、PG2含量与其他三组比较差异均有统计学意义(P<0.05);对照2组患者的PG1、PG2含量及其PGR值与胃癌组比较差异均有统计学意义(P<0.05);对照2组患者的PG1、PG2含量及其PGR值与对照1组比较差异均有统计学意义(P<0.05);各萎缩程度亚组PG1、PG2含量及其PGR值比较差异均有统计学意义(P<0.05);胃窦组PG1、PG2含量均高于非胃窦组,比较差异均有统计学意义(P<0.05)。以PG1≤70 ng/m L且PGR≤4为界值时特异性为68.08%,敏感性为70.59%。结论:采用免疫比浊法检测血清PG1、PG2水平,在胃癌、萎缩性胃炎患者中具有较高的敏感性和特异性,对临床早期诊断有着重要的意义,且具有定量、快速、稳定、成本低,实用性强、检测方便、无辐射等优点。

Objective：To investigate the value of latex-enhanced immunoturbidimetry in clinical detection of PG1,PG2.Method：A total of 50 cases of gastric cancer,who were treated in our hospital from May 2012 to May 2014（gastric group） were selected.75 patients with atrophic gastritis patients（control group 1）,50 patients with peptic ulcer patients（control group 2）,and 50 patients with normal volunteers were selected according to pathology results at the same period（control group 3）.Latex-enhanced immunoturbidimetry was applied in the detection of serum PG1 and PG2 level of four fasting group patients,then they were analyzed.Result：PG1,PG2 content of the control group 3 were compared with that of the other three groups,the differences were statistically significant（P〈0.05）.PG1,PG2 content and PGR scores of the control group 2 were compared with that of the gastric cancer group,the differences were statistically significant（P〈0.05）.PG1, PG2 content and PGR scores of the control group 2 were compared with the control group 1,the differences were statistically significant（P〈0.05）.PG1,PG2 content and PGR scores in each atrophic gastritis subgroups were compared,the differences were statistically significant（P〈0.05）.PG1 and PG2 content in the gastric antrum group were higher than that of the non-gastric antrum group,comparative differences were statistically significant（P〈0.05）.When the value for the community was PGI≤70 ng/m L and PGR≤4,the specificity was 68.08%,and the sensitivity was 70.59%.Conclusion：Using immunonephelometry to detect of serum PG1,PG2 level has high sensitivity and specificity in gastric cancer patients with atrophic gastritis.For early diagnosis,it has important significance, and has a quantitative,rapid,stable,low cost,practical,convenient detection, radiation and other advantages.