摘要
肺动脉高压(pulmonary hypertension,PH)的主要特征是肺动脉血管不同程度的重建,引起肺血管阻力和右室后负荷增加,最终导致右室功能衰竭。野百合碱(monocrotaline,MCT)诱导的大鼠PH模型因为技术的简单性、可重复性、低成本频繁在研究PH的实验中使用。本文综述了MCT诱导PH大鼠模型具体过程,观察其是否能模拟PH患者的丛样病变。
Pulmonary hypertension（PH） is characterized by remodeling of the pulmonary arterial vessels,which increases the pulmonary vascular resistance and right ventricular afterload, thus contributing to the development of right ventricle dysfunction and failure.The monocrotaline（MCT） rat model continues to be a frequently investigated model of PH,since it offers technical simplicity,reproducibility, and low cost compared with other models of PH.This article will define the specific process of PH rat model induced by MCT.Whether this model simulations plexiform vascular lesions of patients with PH.
出处
《中国医学创新》
CAS
2016年第17期142-145,共4页
Medical Innovation of China
关键词
肺动脉高压
野百合碱
大鼠模型
Pulmonary hypertension
Monocrotaline
Rat model
