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5-氨基酮戊酸在光动力和声动力治疗肿瘤中的实验与临床研究进展

Progession of the experimental and clinical research of 5-aminolevulinic acid-based photodynamic and sonodynamic therapy of tumor
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摘要 5-氨基酮戊酸(5-aminolevulinic acid,5-ALA)作为光敏剂、声敏剂已广泛应用于光动力疗法和声动力疗法中。5-ALA通过细胞内代谢产生原卟啉Ⅸ(ProtoporphyrinⅨ,PpⅨ),其具有的光敏性和声敏性可以在激光和超声作用下激活,产生氧自由基或活性氧物质,诱导细胞凋亡、坏死。本文就近年来5-ALA在光、声动力疗法治疗肿瘤中的实验与临床研究进展作一综述。 5-aminolevulinic acid（5-ALA） is a strong photosensitizer, and it is widely used in photodynamic and sonodynamic therapy. 5-ALA is a precursor of PpⅨ which is generally accumulated higher in tumor cells than normal cells. Irradiation and ultra-sound irradiation excitate PpⅨ in tumor cells and produce reactive oxygen species（ROS）, and damage DNA, mitochondria membrane and the other cell membrane then causes the apoptosis, necrosis. This article reviews the experimental and clinical research progression of 5-ALA in photodynamic and sonodynamic therapy of tumor recent years.
作者 许桐瑛 朱文婷 谢蕊 魏孝礼 李燕京 白玉贤
机构地区 哈尔滨医科大学附属肿瘤医院消化内科
出处 《临床肿瘤学杂志》 CAS 2016年第5期469-473,共5页 Chinese Clinical Oncology
基金 国家自然科学基金面上项目(81372610) 国家自然科学基金青年科学基金项目(81401540) 黑龙江省博士后特别资助(LBH-TZ0518)
关键词 5-氨基酮戊酸 光动力疗法 声动力疗法 肿瘤 5-aminolevulinic acid（5-ALA） Photodynamic therapy Sonodynamic therapy Tumor
分类号 R730.5 [医药卫生—肿瘤]
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参考文献45

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临床肿瘤学杂志
2016年 第5期

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