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AEG-1在恶性肿瘤发生发展中的作用机制 被引量：3

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摘要 星形细胞上调基因-1(AEG-1)是一种原癌基因,多项研究均表明该基因在多种恶性肿瘤的发生、发展过程中起着重要作用,能够促进癌症的发生与发展,同时,该基因逐渐成为多种肿瘤临床诊断和预测预后的关键因子。本文就AEG-1基因在肿瘤中的作用机制以及近年来的研究进展做一简要介绍。
作者 邱宇 丁浩 郝晓宁 钟理
机构地区 河北大学生命科学学院生物芯片实验室 美国健康科学西部大学
出处 《诊断病理学杂志》 CSCD 2016年第6期466-469,共4页 Chinese Journal of Diagnostic Pathology
基金 国家自然科学基金资助项目(No.81272444 No.81472744)
关键词 肿瘤 AEG-1 作用机制 文献综述
分类号 R730.49 [医药卫生—肿瘤]
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参考文献33

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  • 2Yoo BK, Emdad L, Lee SG, et al. Astrocyte elevated gene-1 ( AEG-1 ) : a multifunctional regulator of normal and abnormal physiology [ J]. Pharmacol Ther, 2011, 130 ( 1 ) : 1 - 8.
  • 3Emdad L, Sarksr D, Su ZZ, et al. Activation of the nuclear factor kappAB pathway by astrocyte elevated gene-1 : implications for tumor progression and metastasis [ J]. Cancer Res, 2006, 66 (3) : 1509 -1516.
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  • 8Song L, Li W, Zhang H, et al. Over expression of AEG-1 significantly associates with tumour aggressiveness and poor prognosis in human non-small cell lung cancer [ J ]. J Pathol, 2009, 219(3) : 317 -326.
  • 9Yu C, Chen K, Zheng H, et al. Overexpression of astrocyte elevaled gene-1 ( AEG-1 ) is associated with esophageal squamous cell carcinoma ( ESCC ) progression and pathogenesis [J].rcinogenesis, 2009, 30(5) : 894 - 901.
  • 10黄美金,吴雪铭,王春芳,张富亿.AEG-1基因在非小细胞肺癌中的表达及其意义[J].重庆医学,2014,43(5):545-547. 被引量：7

二级参考文献61

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诊断病理学杂志
2016年 第6期

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