摘要
目的了解系统性红斑狼疮(SLE)合并肺部感染患者T淋巴细胞亚群的变化情况,及其与免疫功能正常的肺部感染间的差异。方法应用流式细胞仪对20例SLE合并肺部感染患者(SLE合并肺部感染组)及19例免疫功能正常的肺部感染患者(肺部感染对照组)、20例健康体检者(健康对照组)的T淋巴细胞亚群进行检测及比较。结果与肺部感染对照组相比,SLE合并肺部感染组CD4^+T细胞减少,CD8^+细胞增加,CD4^+/CD8^+比值明显下降(P<0.05)。结论 SLE合并肺部感染患者免疫功能明显下降,在治疗中须给予重视。
Objective To study the change of T lymphocyte subsets in patients of systemic lupus erythematosus（SLE）with pneumonia,and the difference with the T lymphocyte subsets in immunocompetent pneumonia patients. Methods T Lymphocyte subsets of 20 SLE with pneumonia patients（SLE with pneumonia group）,19 immunocompetent pneumonia patients（pneumonia control group）,and 20 healthy subjects（healthy control group）were detected with flow cytometry and compared. Results Com-pared with pneumonia control group,the number of CD4 ＋ T lymphocytes of SLE with pneumonia groups were lower,and the number of CD8 ＋ T lymphocytes were higher,CD4 ＋ / CD8 ＋ ratio was lower（P ﹤ 0. 05）. Conclusion SLE patients with pneumo-nia was immunocompromised,which should be paied attention in the treatment.
出处
《河南医学研究》
CAS
2016年第4期597-599,共3页
Henan Medical Research
基金
河南省教育厅资助基金项目(142300410327)
