清热活血化湿类方药修复肠黏膜上皮屏障治疗溃疡性结肠炎研究近况

Heat-clearing and Blood Circulation-Promoting Formulae Repairing Intestinal Mucosal Epithelial Barrier in Treatment of Ulcerative Colitis

溃疡性结肠炎(UC)是一种病因、发病机制尚不清楚的发于大肠黏膜及黏膜下层的慢性非特异性炎症性肠病。肠黏膜屏障损伤是UC发生的重要机制,近年来肠黏膜屏障在UC发病中的变化受到越来越多的关注。文章通过检索近几年中药对肠黏膜屏障的影响,发现其治疗UC的主要机理是促进肠黏膜紧密连接、降低肠黏膜屏障通透性、抑制肠上皮细胞凋亡及炎症因子释放。由此可见中医药对肠黏膜屏障影响受到广泛重视,修复肠黏膜屏障功能成为治疗UC的重要靶点。

Ulcerative colitis,a intestinal disease of chronic,nonspecific and inflammation which etiology and pathogenesis is not clear,happens in the large intestine mucosa and submucosa. Intestinal mucosa barrier damage is one of the important mechanisms in the occurrence of UC. Recently,intestinal mucosal function has attracted increasing attention. This article,by retrieving the influence of traditional Chinese medicine on intestinal mucosa barrier in recent years,found that the main treatment of UC is promoting intestinal mucose,reducing the intestinal mucosal barrier permeability,inhibiting the intestinal epithelial cell apoptosis and the release of inflammatory cytokines. Therefore,we can find traditional Chinese medicine has been widely paid attention to.To repair the intestinal mucosal barrier function has become the important target for the treatment of UC.