鼻塞式持续气道正压通气在胎龄≥32周早产儿呼吸窘迫综合征的疗效观察

Efficacy of nasal continuous positive airway pressure on premature infant gestational age ≥32 weeks with respiratory distress syndrome

目的:对鼻塞式持续气道正压通气治疗胎龄≥32周早产儿呼吸窘迫综合征的疗效进行研究。方法:选取98例胎龄≥32周的呼吸窘迫综合征早产儿,随机分为观察组(49例)和对照组(49例),两组均予以常规治疗,对照组在常规治疗的基础上予以头罩吸氧,观察组予以鼻塞式持续气道正压通气(NCPAP),比较两组血气指标及临床疗效。结果:治疗前两组Pa O2,Pa CO2差异无统计学意义(P>0.05);治疗后两组Pa O2均明显上升,与治疗前比较,差异具有统计学意义(P<0.05),观察组治疗6 h、12 h、24 h Pa O2高于对照组,差异有统计学意义(P<0.05),两组Pa CO2均下降,与治疗前比较,差异无统计学意义(P>0.05),两组6 h、12 h、24 h Pa O2差异无统计学意义(P>0.05);观察组治疗成功率87.8%,高于对照组的63.3%,差异有统计学意义(P<0.05)。结论:鼻塞式持续气道正压通气治疗胎龄≥32周的呼吸窘迫综合征早产儿疗效显著,有助于改善动肺换气功能,具有积极的应用价值。

Objective To explore the efficacy of nasal continuous positive airway pressure in treatment of premature infant gestational age ≥32 weeks with respiratory distress syndrome. Method 98 cases of premature infant gestational age ≥32 weeks with respiratory distress syndrome were randomly divided into the observation group（ 49 cases） and the control group（ 49 cases）,both groups received conventional treatment,the control group on the basis of conventional treatment received hood oxygen,the observation group was treated with nasal continuous positive airway pressure（ NCPAP）,the blood gas index and clinical curative effect were compared in two group. Results The PaO2,PaCO2 difference of the two groups before treatment had not statistically significant（ P〈0. 05）,the PaO2 of the two groups after treatment increase significantly,compared with before treatment the difference had statistically significant（ P〈0. 05）,the PaO2 of the observation group at 6,12,24 h were higher than the control group（ P〈0. 05）; the PaCO2 of the two groups after treatment reduced,compared with before treatment the difference had no statistically significant（ P〈0. 05）,the PaO2 difference of two groups at 6、12、24 h had no statistically significant（ P〈0. 05）,the treatment success rate of the observation group 87. 8% was higher than the control 63. 3%（ P〈0. 05）. Conclusion NCPAP in treatment of premature infant gestational age ≥32 weeks with respiratory distress syndrome has a define effect,contribute to improve the pulmonary ventilation function,and has application value positive.