心衰合剂对慢性心力衰竭患者症状改善和N末端-脑钠肽前体(NT-proBNP)的影响

The Effect of Xinshuai Mixture on Improvement of Symptoms in Patients with Chronic Heart Failure and NT-proBNP

目的观察心衰合剂对慢性心力衰竭患者症状改善和N末端-脑钠肽前体(NT-proBNP)的影响。方法筛选慢性心力衰竭C阶段射血分数保留性心衰(HFpEF)和射血分数降低性心衰(HFrEF)同时符合中医气阴两虚血瘀证患者80例,按随机数字表法分为治疗组与对照组各40例。所有患者均接受西药常规规范化治疗。中药组给予心衰合剂12周,疗程结束后统计并比较两组中医证候积分和NT-proBNP水平。结果两组治疗后中医证候积分和NT-proBNP与本组治疗前比较差异有统计学意义(P<0.01),治疗后组间比较,差异亦有统计学意义(P<0.05)。结论中药心衰合剂对于慢性心力衰竭C阶段HFpEF和HFrEF治疗,可明显改善患者证候,显著降低血浆NT-proBNP水平,改善其预后,提高生活质量,中西医结合治疗慢性心力衰竭较单纯西医治疗效果更加,临床应用安全。

Objective： To observe the effect of Xinshuai mixture on the symptoms of chronic heart failure patients and N terminal brain natriuretic peptide（NT-proBNP）. Methods： 80 patients with HFpEF and HFrEF,meanwhile,according with Chinese medicine syndrome diagnosis of Qi and yin deficiency and blood stasis,were selected,and randomly divided into two groups,40 in each. All patients received conventional Western medicine treatment. TCM group took Xinshuai mixture for 12 weeks. After treatment,TCM syndrome score and NT-proBNP level change were compared between the two groups. Results： Before treatment,there was significant difference between the two groups in TCM syndrome integral and NT-proBNP after treatment,as well as the comparison between the two groups after treatment（P〈0.01 or P〈0.05）. Conclusion： Xinshuai mixture on HFpEF and HFrEF can significantly improve patient′ s syndrome,reduced the level of NT-proBNP,improve the prognosis and the quality of life,which has a better effect and safe in clinical application,compared with only Western medicine treatment.