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他汀类药物用于多发性硬化的基础及临床研究 被引量:4

The basic and clinical research of statins for multiple selerosis
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摘要 大量研究证实,他汀类药物具有免疫调节、抗炎和神经保护作用,其多效性作用对免疫调节紊乱性疾病如多发性硬化(MS)是一种有吸引力的治疗选择,激励着越来越多研究者关注他汀在临床上的应用。 Numerous studies have confirmed that statins have immunomodulatory, anti-inflammatory and neuroprotective effects. Those pleiotropic effects make statins an attractive treatment option for immune-me- diated disorders such as multiple sclerosis. More and more researchers focus on the clinical application of st- atins. However, there is still potential antagonism in the clinical trials of starins.
作者 李玉霞 王荔
出处 《国际免疫学杂志》 CAS 2016年第3期307-311,共5页 International Journal of Immunology
关键词 他汀类药物 多发性硬化 免疫调节作用 神经保护作用 Statins Multiple sclerosis Immunomodulatory effect Neuroprotection
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参考文献37

  • 1Zhang X,Tao Y, Wang J,et al. Simvastatin inhibits secretion of-Thl7-polarizing cytokines and antigen presentation by DCs in pa-tients with relapsing remitting multiple sclerosis[ J]. Eur J Immu-nol,2013,43(1) :281-289.
  • 2Lee SJ, Qin H, Benveniste EN. The IFN-gama-induced transcrip-tional program of the CIITA gene is inhibited by statins[ J]. Eur JImmunol, 2008,38 ( 8 ): 2325-2336.
  • 3Bums EMI,Smelser LK,Then JE,et al. Short term statin treatmentimproves survival and differentially regulates macrophage-mediatedresponses to staphylococcus aureus [ J ]. Curr Pharm Biotechnol,2013,14(2) :233-241.
  • 4Kilic U,Gok O,Elibol-Can B,et al. Efficacy of statins on sirtuin 1and endothelial nitric oxide synthase expression: the role of sirtuin1 gene variants in human coronary atherosclerosis[ J]. Clin ExpPharmacol Physiol,2015,42 (4) : 321 -330.
  • 5Tokuhara K,Habara K,Oishi M,et al. Fluvastatin inhibits the in-duction of inducible nitric oxide synthase, an inflammatory biomar-ker, in hepatocytes[ J]. Hepatol Res,2013,43(7) :775-784.
  • 6Youssef S,Stuve O,Patarroyo JC,et al. The HMG-CoA reductaseinhibitor, atorvastatin, promotes a Th2 bias andreverses paralysis incentral nervous system autoimmune disease [ J ]. Nature, 2002,420(6911) :7844.
  • 7Van Der Putten C,Kuipers HF,Zuiderwijk-Sick EA,et al. Statinsamplify TLR-induced responses in microglia via inhibition of cho-lesterol biosynthesis [ J ]. Glia, 2012 , 60 (1 ) ; 43-52.
  • 8de Oliveira DM,de Oliveira EM, Ferrari Mde F, et al. Simvastatinameliorates experimental autoimmune encephalomyelitis by inhibi-ting Thl/Tlil7 response and cellular infiltration [ J ]. Inflammop-harmacology,2015,23(6) :343-354.
  • 9Satoh M, Takahashi Y, Tabuchi T, et al. Cellular and molecularmechanisms of statins : an update on pleiotropic effects [ J ]. Clin Sci(Lond) ,2015,129(2) :93 405.
  • 10田广平,石秋艳,王淑歌,孙惠芳,孙鹏,张瑞彪.阿托伐他汀对EAE大鼠脊髓ICAM-1和TGF-β1表达的影响[J].中华神经医学杂志,2011,10(10):979-983. 被引量:6

二级参考文献58

  • 1辛晋敏,马存根,梁丽云,马太花,尉杰忠.细胞间黏附分子-1在实验性自身免疫性脑脊髓炎大鼠中表达的动态变化及作用[J].中国神经免疫学和神经病学杂志,2006,13(2):77-81. 被引量:10
  • 2徐全刚,王晓辉,任晓暾,黄德晖,吴卫平.干扰素β-1b对实验性自身免疫性脑脊髓炎脊髓中趋化因子MCP-1表达的影响[J].中华神经医学杂志,2007,6(3):290-292. 被引量:5
  • 3Youssef S, Stuve O, Patarroyo JC, et al. The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease [J]. Nature, 2002, 420(6911): 78-84.
  • 4Nath N, Girl S, Prasad R, et al. Potential targets of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor for multiple sclerosis therapy[J]. J Immunol, 2004, 172 (2) 1273-1286.
  • 5Waiczies S, Bendix I, Prozorovski T, et al. Geranylgeranylation but not GTP loading determines rho migratory fuction in T cells [J]. J Immunol, 2007, 179 (9): 6024-6032.
  • 6Schulz JG, Bosel J, Stoeckel M, et al. HMG-CoA reductase inhibition causes neurite 1 oss by interfering with geranylgeranylpyrophosphate synthesis [J]. J Neurochem, 2004, 89(1): 24-32.
  • 7Jeong EM, Moon CH, Kim CS, et al. Cadmium stimulates the expression of ICAM-1 via NF-kappa B activation in cerebrovascular endothelial cells [J]. Biochem Biophys Res Commun, 2004, 320(3): 887-892.
  • 8Bullard DC, Hu X, Schoeb TR, et al. Intercellular adhesion molecule-1 expression is required on multiple cell types for the development of experimental autoimmune encephalomyelitis [J]. J Immunol, 2007, 178(2): 851-857.
  • 9Mix E, Ibrahim SM, Pahnke J, et al. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor Atorvastatin mediated effects depend on the activation status of target cells in PLP-EAE [J]. J Autoimmun, 2006, 27(4): 251-265.
  • 10Chitnis T, Khoury SJ. Cytokine shifts and tolerance in experimental autoimmuneencephalomye-litis [J]. J Immunol, 2003, 28 (3): 223-239.

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