摘要
目的:观察100例经凉血解毒法治疗湿热瘀毒证型重型乙型肝炎的转归,评价相关实验室指标与疾病的关系。方法:100例湿热瘀毒证型重型乙型肝炎患者均在西医一般治疗基础上,予清肝解毒注射液静滴、大黄水煎液灌肠。观察治疗前后患者实验室指标变化情况。结果:治疗后患者症状和体征改善,血常规、电解质、白蛋白(ALB)、肾功能、白介素-2(IL-2)无明显变化(P>0.05);丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(DBi L)、血氨(NH3)、超敏C反应蛋白(hs-CRP)、肿瘤转化因子-α(TNF-α)、白介素-8(IL-8)降低,凝血酶原活动度(PTA)、白介素-10(IL-10)升高,差异均具有统计学意义(P<0.05)。100例入组患者总有效率为55.0%。结论:凉血解毒法对湿热瘀毒证型重型乙型肝炎安全有效,密切监测实验室指标有助于提高重型乙型肝炎的诊治。
Abstract Objective:To evaluate the clinical effects of cooling blood and removing blood toxin method in treating chronic severe hepatitis B patients with the type of heat-dampness, stasis and toxin. Methods: A hundred patients with severe hepatitis B were treated with cooling blood and removing blood toxin method. Results:Patients with symptoms and signs improved after treatment. There was no significant difference in blood routine test results, electrolytes, renal function, albumin (ALB), interleukin-2 (IL- 2) (P 〉0.05). ALT, AST, DBiL, TBiL, GGT, NH3, hs-CRP, TNF-a, IL-8 were decreased compared with those before the treatment with statistically significance (P 〈 0. 01 ;P 〈 0. 05 ), while PTA and IL-10 were increased compared with those before the treatment (P 〈 0. 05 ) without any significant difference (P 〉 0. 05 ). The total effective rate was 55.0%. Conelusion: Cooling blood and removing blood toxin method in treating chronic severe hepatitis B may be safe and effective, close monitoring for labora- tory indicators may help the diagnosis and treatment of severe hepatitis B.
出处
《世界中医药》
CAS
2016年第5期838-841,共4页
World Chinese Medicine
基金
浙江省医院可持续发展华润三九研究基金项目(编号:2014ZHA-HRSJ212)
关键词
凉血解毒
重型乙型肝炎
实验室指标
评价
Cooling blood and removing blood toxin method
Chronic severe hepatitis B
Laboratory indicators
Evaluation