凉血解毒法治疗重型乙型肝炎实验室指标评价

Laboratory Evaluation of Cooling Blood and Removing Blood Toxin Method Treating Chronic Severe Hepatitis B

目的:观察100例经凉血解毒法治疗湿热瘀毒证型重型乙型肝炎的转归,评价相关实验室指标与疾病的关系。方法:100例湿热瘀毒证型重型乙型肝炎患者均在西医一般治疗基础上,予清肝解毒注射液静滴、大黄水煎液灌肠。观察治疗前后患者实验室指标变化情况。结果:治疗后患者症状和体征改善,血常规、电解质、白蛋白(ALB)、肾功能、白介素-2(IL-2)无明显变化(P>0.05);丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(DBi L)、血氨(NH3)、超敏C反应蛋白(hs-CRP)、肿瘤转化因子-α(TNF-α)、白介素-8(IL-8)降低,凝血酶原活动度(PTA)、白介素-10(IL-10)升高,差异均具有统计学意义(P<0.05)。100例入组患者总有效率为55.0%。结论:凉血解毒法对湿热瘀毒证型重型乙型肝炎安全有效,密切监测实验室指标有助于提高重型乙型肝炎的诊治。

Abstract Objective：To evaluate the clinical effects of cooling blood and removing blood toxin method in treating chronic severe hepatitis B patients with the type of heat-dampness, stasis and toxin. Methods： A hundred patients with severe hepatitis B were treated with cooling blood and removing blood toxin method. Results：Patients with symptoms and signs improved after treatment. There was no significant difference in blood routine test results, electrolytes, renal function, albumin （ALB）, interleukin-2 （IL- 2） （P 〉0.05）. ALT, AST, DBiL, TBiL, GGT, NH3, hs-CRP, TNF-a, IL-8 were decreased compared with those before the treatment with statistically significance （P 〈 0. 01 ;P 〈 0. 05 ）, while PTA and IL-10 were increased compared with those before the treatment （P 〈 0. 05 ） without any significant difference （P 〉 0. 05 ）. The total effective rate was 55.0%. Conelusion： Cooling blood and removing blood toxin method in treating chronic severe hepatitis B may be safe and effective, close monitoring for labora- tory indicators may help the diagnosis and treatment of severe hepatitis B.