电针联合雷头风颗粒治疗原发性三叉神经痛临床研究

A clinical study of electro-acupuncture combined withLeitoufeng granules for primary trigeminal neuralgia

目的：评价电针联合雷头风颗粒治疗原发性三叉神经痛（primary trigeminal neuralgia, PTN）的临床疗效。方法将符合入选标准的60例PTN患者按病历尾号随机分为2组各30例，对照组口服卡马西平，治疗组在对照组基础上加用电针联合雷头风颗粒。15 d为1个疗程，共治疗3个疗程。采用简化McGill疼痛问卷（A Short Form of the McGill Pain Questionnaire, SF-MPQ）比较治疗前后疼痛评定指数（painratingindex, PRI）、选词数（number of word chosen, NWC）、现时疼痛强度（present painindex, PPI）、视觉模拟量表（Visual Analogue Scale, VAS）分值的变化，评价临床疗效并观察复发率。结果治疗组愈显率为96.7%（29/30），对照组为70.0%（21/30），2组比较差异有统计学意义（χ2＝5.880，P＝0.015）。治疗后，治疗组 PRI[（0.20±0.47）分比（3.33±4.65）分，t＝3.592]、NWC[（0.20±0.48）分比（1.40±1.87）分，t＝3.345]、VAS[（0.20±0.48）分比（1.27±1.66）分，t＝3.321]、PPI[（0.17±0.38）分比（0.90±0.99）分，t＝3.771]、总分[（0.79±1.83）分比（6.90±9.05）分，t＝3.602]分值均低于对照组（P＜0.01）；治疗组 PTN 日发作频次[（2.20±1.17）次比（4.27±1.39）次，t＝6.238]低于对照组（P＜0.01）。随访3个月，治疗组复发3例（10.0%），对照组复发17例（56.6%），2组比较差异有统计学意义（χ2＝12.675，P＜0.01）。结论电针联合雷头风颗粒治疗PTN疗效优于卡马西平。

Objective To detect the therapeutic effectiveness of electro-acupuncture combined with Leitoufenggranules for primary trigeminal neuralgia.MethodsA total of 60 patients with PTN were randomly divided into the control group and the treatment group （30 in each group）. Control group received Carbamazepine, and the treatment group received the electro-acupuncture combined withLeitoufeng granules. Both groups were treated for 15 days as a period of treatment with 3 treatments in total. The outcomes were S hort form of the McGill Pain Questionnaire （SF-MPQ）, painratingindex （PRI）, the number of word feature （NWC）, the present painindex （PPI）, the Visual Analogue Scale （VAS） the clinical effect rate and recurrence rate. Results After treatment, compared with the control group, the effect rate （96.67%vs. 70.00%,χ2=5.880,） in the treatment group showed significantly higher （P=0.015）. Compared with the control group, PRI （0.20 ± 0.47 vs. 3.33 ± 4.65,t=3.592）, NWC （0.20 ± 0.48vs. 1.40 ± 1.87,t=3.345）, VAS （0.20 ± 0.48vs. 1.27 ± 1.66, t=3.321）, PPI （0.17 ± 0.38vs.0.90 ± 0.99,t=3.771） and the total score （0.79 ± 1.83vs. 6.90 ± 9.05,t=3.602） in the treatment group were significantly lower （P〈0.01）. In the follow-up of 3 months, compared with control group, the recurrence rate （10.0%vs.56.6%,χ2=12.675） in the treatment group significantly lower （P〈0.01）. Conclusion As to the treatment of primary trigeminal neuralgia, the effect of acupuncture combined with Leitoufeng granules was superior to the Carbamazepine.