阿司匹林联合氯吡格雷治疗大脑中动脉狭窄脑梗死的有效性

Effect of aspirin combined with clopidogrel in the treatment of patients with cerebral infarction of middle cerebral artery stenosis

目的：探讨阿司匹林与氯吡格雷联用对大脑中动脉狭窄脑梗死的有效性。方法选取88例大脑中动脉狭窄脑梗死患者，按治疗方法的不同将其随机分为A、B两组，每组44例。 A组单独应用阿司匹林进行治疗；B组在应用阿司匹林治疗的同时联用氯吡格雷治疗。观察并比较A、B两组治疗效果。结果 B组总体治疗有效率高达90．91％，高于A组的75．00％，差异有统计学意义（χ2＝3．938，P＜0．05）。 B组脑梗死进展率和复发率分别为6．82％和4．55％，均低于A组的27．27％和20．45％，差异均有统计学意义（χ2＝7.639、5．091，均P＜0．05）。治疗后B组改良Barthel指数得分与改良Fugl-Meyer得分均优于A组，差异均有统计学意义（均P＜0．05）。结论阿司匹林与氯吡格雷联用治疗大脑中动脉狭窄脑梗死疗效显著，且可降低脑梗死的进展率和复发率，值得临床推广应用。

Objective To analyze the effect of aspirin combined with clopidogrel in the treatment of patients with cerebral infarction of middle cerebral artery stenosis.Methods 88 patients with cerebral infarction of middle cerebral artery stenosis were selected and divided into group A and B based on the methods of treatment,44 patients in each group.Patients in group A were given aspirin, and patients in group B were given aspirin combined with clopidogrel.The effects of the group A and B were observed and compared.Results The total effective rate of group B was 90.91%,which was higher than 75.00%（33/44） of group A,the difference was statistically significant（χ2 =3.938,P〈0.05）.The progression rate and relapse rate of group B were 6.82%and 4.55%,which were lower than 27.27%and 20.45%of group A,and the differences were statistically significant（χ2 =7.639,5.091,all P〈0.05）. The scores of modified Barthel Index and modified Fugl-Meyer in group B were all better than the scores in group A after treatment,and the differences were statistically significant（all P〈0.05）.Conclusion It is effective for aspirin combined with clopidogrel to treat the patients with cerebral infarction of middle cerebral artery stenosis,which can decrease the rate of progression and relapse,and worthy of clinical application.