卡托普利联合硝苯地平缓释片治疗2型糖尿病合并高血压的疗效观察

Clinical curative effect of captopril combined with nifedipine sustained-release tablets in the treatment of hypertension in patients with type 2 diabetes

目的：探索卡托普利联合硝苯地平缓释片治疗2型糖尿病合并高血压的临床疗效。方法将100例2型糖尿病合并高血压患者选为研究病例并采用随机、单盲法将其分作两组，两组均给予常规降糖治疗，其中对照组50例予卡托普利治疗，观察组50例予卡托普利联合硝苯地平缓释片治疗，对比两组临床治疗效果。结果观察组有效率94．00％，较对照组的80．00％明显提高，差异有统计学意义（χ2＝9．65，P＜0.05）。观察组患者经治疗后舒张压（80．45±3．65）mmHg、收缩压（128．67±5．66）mmHg、空腹血糖（6．65±0．37）μmol／L、餐后2 h血糖（9．76±1．22）μmol／L均较治疗前明显减少（t＝8．06、8．18、8．00、7．94，均P＜0.05），且舒张压和收缩压与对照组差异有统计学意义（t＝8．66、7．90，均P＜0．05）。观察组患者经治疗后血清肌酐（97．44±6．32）μmol／L、尿素氮（4．20±0．30）mmol／L及24 h尿微量白蛋白（17．99±4．10）mg／L均较治疗前明显减少（t＝7．67、8．27、8．32，均P＜0．05），且各项指标与对照组差异有统计学意义（t＝7．23、7．65、7．67，均P＜0．05）。结论托普利联合硝苯地平缓释片治疗2型糖尿病合并高血压疗效显著，可有效降低患者血压，改善肾功能，具有临床应用和推广价值。

Objective To explore the clinical efficacy of captopril combined with nifedipine in the treatment of type 2 diabetes mellitus complicated with hypertension.Methods 100 patients with type 2 diabetes mellitus complicated with hypertension were divided into two groups by randomized single blind method.The two groups were given conventional hypoglycemic therapy,50 cases in the control group were treated with captopril,while 50 cases in observation group received captopril combined with nifedipine sustained -release tablets.The clinical therapeutic effect was compared between the two groups.Results The effective rate of the observation group was 94%,which of the control group was 80%,the difference was statistically significant （χ2 =9.65,P〈0.05）.After treatment,the diastolic blood pressure[（80.45 ±3.65）mmHg],systolic blood pressure[（128.67 ±5.66）mmHg],fasting blood glucose[（6.65 ±0.37）μmol/L],2h postprandial blood glucose[（9.76 ±1.22）μmol/L]of the observation group were significantly reduced than before treatment （t =8.06,8.18,8.00,7.94,all P 〈0.05）,and diastolic blood pressure and systolic blood pressure were significantly different with the control group（t=8.66,7.90,all P〈0.05）. After treatment,the serum creatinine （97.44 ±6.32）μmol/L,urea nitrogen （4.20 ±0.30） mmol/L and 24h urinary albumin （17.99 ±4.10） mg/L of the observation group were significantly reduced compared with before treatment （t=7.67,8.27,8.32,all P〈0.05）,and the indicators had significant differences with the control group（t=7.23, 7.65,7.67,all P〈0.05）.Conclusion Captopril and nifedipine sustained-release tablets in the treatment of type 2 diabetic patients with hypertension can effectively reduce the blood pressure,improve renal function,and it has good clinical application and promotion value.