不同类型β地中海贫血儿童体液免疫的研究

Study on humoral immunity in children with different types of beta

目的探讨体液免疫系统的免疫球蛋白及补体水平变化在不同类型β地中海贫血儿童中的临床诊断价值。方法选择2014年5月—2015年10月在我院儿科确诊及治疗的不同类型β地中海贫血儿童50例为观察组,并选取同期正常体检儿童100例设为对照组。检测两组对象的免疫球蛋白Ig A、Ig M、Ig G以及补体C3、C4水平。结果观察组与对照组比较,Ig A、Ig M水平明显高于对照组(P<0.05),补体C3、C4水平明显低于观察组(P<0.05);观察组不同类型的β地中海贫血的结果中,中重度组的免疫球蛋白水平明显高于轻度组(P<0.05),补体C3、C4水平明显低于轻度组(P<0.05)。结论不同类型不同程度的β地中海贫血儿童,体液免疫功能的表达不一样,监测免疫球蛋白以及补体水平变化,可对不同类型β地中海贫血儿童的诊疗及预后有一定的作用。

Objective： To investigate the clinical diagnostic value of immunoglobulin and complement levels in children with different types of beta. Methods： 50 cases of children with beta Mediterranean anemia diagnosed and treated in our hospital from May 2014 to October 2015 were selected as observation group, and 100 normal children were selected as control group. IgA, IgM, GIg and complement C3, C4 levels were detected in the two groups. Results： in the observation group and the control group, IgA, IgM level was significantly higher than that of control group （P〈 0.05） , the levels of complement C3 and C4 was significantly lower than that of the observation group （P〈 0.05）; observed in the group of different types of beta thalassemia result, group with severe immune globulin level was significantly higher than that of mild group （P〈 0.05） , the levels of complement C3 and C4 was significantly lower than that of the mild group （P〈 0.05） . Conclusion： different types of different level of beta thalassemia children, the expression of humoral immune function is not the same, monitoring immune globulin protein and complement level changes, for different types of beta thalassemia Anemia Diagnosis and prognosis of children have a certain role.