多奈哌齐对急性一氧化碳中毒患者认知障碍的预防效果

Preventive effect of donepezil on cognitive impairment in patients with acute carbon monoxide poisoning

目的探讨多奈哌齐对急性一氧化碳中毒患者认知障碍的预防效果。方法选取2012年1月至2015年1月急性一氧化碳中毒患者40例，依据治疗方案分为低剂量组及高剂量组，每组20例。两组均给予基础治疗，低剂量组晚间口服盐酸多奈哌齐片5mg，高剂量组晚间口服盐酸多奈哌齐片10mg，持续3个月。比较两组患者治疗前后认知功能。结果治疗后两组患者的认知功能均有改善，但高剂量组优于低剂量组[（22．36±1．13）比（21．01±0．97）]，差异有统计学意义（P〈0．05）。结论多奈哌齐改善急性一氧化碳中毒患者的认知功能安全有效，高剂量效果更佳，但需进一步研究。

Objective To investigate the preventive effect of donepezil on cognitive impairment in patients with acute carbon monoxide poisoning. Methods From January 2012 to January 2015, 40 patients with acute carbon monoxide poisoning were selected, and were divided into low-dose group and high-dose group according to the treatment plans, with 20 cases in each group. The two groups were given basic treatment, the low-dose group was given donepezil hydrochloride tablets 5 mg in the evening of oral, while high-dose group received that 10 rag, for the last 3 months, and compard the two groups of cognitive function before and after the treatment. Results Cognitive function was improved inthe two groups after treatment, but the high dose group was better than the low dose group[ （22. 36 ± 1.13） vs（21.01 ±0.97）], the difference was significant（P 〈0.05）. Conclusions Donepezil can improve cognition in patients with acute carbon monoxide poisoning, is safe and effective, high dose effect is better, but needs to be studied further.