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甲钴胺联合加巴喷丁治疗糖尿病痛性神经病变疗效分析 被引量:5

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摘要 目的观察甲钴胺联合加巴喷丁治疗糖尿病痛性神经病变的安全性及疗效。方法将60例糖尿病痛性神经病患者采用随机数字表法随机分为治疗组与对照组,每组30例。治疗组采用甲钴胺联合加巴喷丁进行治疗,观察组采用常规治疗,观察治疗前后两组患者的临床症状及肌电图检查结果。结果治疗组的总有效率显著高于对照组(P=0.018)。结论甲钴胺联合加巴喷丁治疗可以明显缓解患者疼痛,对于中、重度患者药物联合治疗可有效缓解疼痛引起的不适。
作者 张桂芬
出处 《中国实用医刊》 2016年第11期100-101,共2页 Chinese Journal of Practical Medicine
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  • 1渠胜英,陈兴华,姚革.糖尿病周围神经病变微血管机制的临床研究[J].放射免疫学杂志,2004,17(3):171-173. 被引量:7
  • 2POLMER V, SOARES JC, ROCHA JB. Oxidative stress in mi~ is dependent on the glucose content of the diet[J]. Int J Biochem Cell Biol, 2002, 34(10): 1279-1285.
  • 3ZIEGLER D, SIEKIERKA-KLEISER E, MEYER B, et al. Validation of a novel screening device (NeuroQuick) for quantitative assessment of small nerve fiber dysfunction as an early feature of diabetic polyneuropathy[J]. Diabetes Care, 2005, 28(5): 1169-1174.
  • 4TESFAYE S, SELVARAJAH D. Advances in the epidemiology, pathogenesis and management of diabetic peripheral neuropathy [J]. Diabetes Metab Res Rev, 2012, 28(Suppl 1): 8-14.
  • 5JACK M, WRIGHT D. Role of advanced glycation endproducts and glyoxalase I in diabetic peripheral sensory neuropathy [J]. Transl Res, 2012, 159(5): 355-365.
  • 6ZHANG L, ZHAO H, BLAGG BS, et al. C-terminal heat shock protein 90 inhibitor decreases hyperglycemia-induced oxidative stress and improves mitochondrial bioenergetics in sensory neurons[J]. J Proteome Res, 2012, 11(4): 2581-2593.
  • 7YAMAGISHI S, UEHARA K, OTSUKI S, et al. Differential influence of increased polyol pathway on protein kinase C expressions between endoncurial and epineurial tissues in diabetic mice[J]. J Neurochem, 2003, 87(2): 497-507.
  • 8HOFMANN MA, KOHL B, ZUMBACH MS, et al. Hyperhomo- cysteine mia and endothelial dysfunction in IDDM [J]. Diabetes Care, 1997, 20(12): 1880-1886.
  • 9AMBROSCH A, DIERKES J, LOBMANN R, et al. Hyperhomo- cysteinemia and endothelial dysfunction in IDDM[J]. Diabet Med, 2001, 18(3): 185-192.
  • 10JIN L, CALDWELL RB, L-I MASTERS T, et al. Homocysteine induces endothelial dysfunction via inhibition of arginine transport[J]. J Physiol Pharmacol, 2007, 58(2): 191-206.

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