乳腺叶状肿瘤并导管内癌及混合性浸润性导管癌伴产生软骨基质的癌一例病理分析及文献复习

Phyllodes tumor, intraductal carcinoma, mixed invasive ductal carcinoma, and metaplastic carcinoma producing cartilage matrix of breast：a case report and review of the literature

目的探讨叶状肿瘤并导管上皮癌变的临床病理特征。方法综合分析研究1例叶状肿瘤并上皮成分癌变患者的临床资料、大体图像、HE形态、免疫组化特征及会诊资料等，了解该肿瘤的病理特征。结果患者为叶状肿瘤并导管内癌及混合性浸润性导管癌产生软骨基质的癌。结论叶状肿瘤可以伴有导管内癌，甚至是浸润性癌。按规范要求，对较大肿瘤多取材，小标本全部取材，结合免疫组化等检查及会诊有助于少见肿瘤病理类型的发现与诊断。

Objective To investigate the clinical and pathological features of phyllodes tumors and ductal epithelial canceration. Methods The clinical data, general picture, HE morphological, immunohistochemical features, and consultation information of one patient with phyllodes tumors and ductal epithelial canceration was studied, in order to understand the characteristics of the tumor. Results The case was phyllodes tumor, intraductal carcinoma, mixed invasive ductal carcinoma, and metaplastic carcinoma producing cartilage matrix of breast. Conclusions Phyloodes tumors can be with intraducatal carcinoma, even invasive cancer.For larger tumors, pathologic sampling even whole serial sections combined with immunohistochemistry examination and consultation can help find rare tumor types.