黏膜相关淋巴样组织淋巴瘤易位蛋白功能及其在血液肿瘤中对核因子-κB信号通路的调节作用

Function of mucosa-associated lymphoid tissue lymphoma translocation protein 1 and its regulation of nuclear factor-κB signaling pathway in hematologic neoplasms

在机体适应性免疫反应中，黏膜相关淋巴样组织淋巴瘤易位蛋白（MALT）1是抗原诱导的核因子-κB信号通路激活的关键因子，其蛋白酶活性的激活可增强机体免疫反应。近年来，相关研究结果表明，MALT1的蛋白酶活性对MALT1依赖性淋巴瘤[活化B细胞样亚型弥漫大B细胞淋巴瘤（ABC—DLBCL）与MALT淋巴瘤]细胞生存及增殖是必需的；亦有文献报道，MALT1与急性T淋巴细胞白血病（T—ALL）、急性B淋巴细胞白血病（KALL）的发生相关，且在骨髓瘤细胞株中过表达。笔者拟就MALT1的功能、对核因子-κB信号通路的调节作用及其与血液系统肿瘤的关系进行综述。

Mucosa-associated lymphoid tissue lymphoma transloeation protein （MALT） 1 is a key regulator of antigen-induced nuclear factor-κB activation in the adaptive immune response. Activation of proteolytic activity of the MALT1 is shown to boost the immune response. Recent studies have shown that MALT1 proteolytic activity was essential for the survival and proliferation of cells of MALTl-dependent lymphoma, such as activated B cell-like diffuse large B cell lymphoma （ABC-DLBCL） and MALT lymphoma. It was also reported to he associated with the development of T cell acute lymphohlastic leukemia （T-ALL） or B-cell acute lymphoblastic leukemia （B-ALL）,and it was overexpressed in myeloma cell lines. This article reviews literatures on the function of MALT1 and its regulation of nuclear factor-κB signaling pathway.