基于中医传承辅助系统的治疗妊娠恶阻组方规律分析

Analysis of Combination Rules of Prescriptions for Pregnant Vomit Based on Traditional Chinese Medicine Inheritance System

目的 :分析和总结中国知网数据库(CNKI)中治疗妊娠恶阻方剂的组方规律。方法 :运用中医传承辅助系统提取CNKI中治疗妊娠恶阻的方剂,整理录入方剂信息,构建数据库,使用软件的关联规则、改进的互信息法、复杂系统熵聚类、无监督的熵层次聚类等数据挖掘方法,分析治疗妊娠恶阻方剂的常用药物、组合规律及核心组合。结果:通过对129首治疗妊娠恶阻方剂的分析,总结出使用20次以上的中药16味、常用药对及药物组合28个、核心组合32个,演化得到新处方9个。结论:CNKI中收录治疗妊娠恶阻的方剂组方以健脾益气、理气止呕为主,辅以辨证加减,可为临床治疗和新药开发提供参考依据。

Objective：To analyze and summarize the combination rules of prescriptions for pregnant vomit in China national knowledge infrastructure（CNKI）. Methods：The information of prescriptions for pregnant vomit in CNKI were selected and analyzed by traditional Chinese medicine inheritance system（TCMIS） and a database was established. The commonly used herbs,combination rules and core combinations in the prescriptions for pregnant vomit were analyzed by data mining methods such as association rules,improved mutual information method and complex system entropy clustering. Results：Through analysis of 129 prescriptions for pregnant vomit,the frequency of commonly used herbs and association rules were defined. A total of 16 Chinese herbs which used more than 20 times,28 commonly used herb pairs and combinations,32 core combinations and 9 developed prescriptions were concluded. Conclusion：The prescriptions for pregnant vomit in CNKI mainly focused on invigorating spleen and tonifying Qi,regulating Qi and stopping vomit. At the same time,the prescriptions were modified according to syndrome differentiation,which provides references for clinical treatment and development of new drugs.