基于数据挖掘探讨张鸣鹤治疗类风湿关节炎活动期用药规律

Exploration of ZHANG Minghe's Medication Rules in Treatment of Rheumatoid Arthritis at Active Stage by Data Mining Method

目的 :运用数据挖掘方法分析张鸣鹤老师治疗类风湿关节炎(Rheumatoid Arthritis,RA)活动期的用药规律。方法:筛选张老师治疗活动期RA的有效处方,录入中医传承辅助系统,分析用药频次、组方规律并发掘新处方。结果:筛选有效处方99首,共计69味药。在"用药频次"模块提取20味高频使用药物,其中以清热解毒和祛风除湿类药物使用频率最高;在"组方规律"模块分析药物关联规则,显示清热解毒药与祛风除湿药相关性最高,其次为利湿药;在"新处方"模块发现张老师治疗RA多以清热、祛风湿、利水、活血、温里药物相配伍,且注重同类药物相须为用。结论:针对活动期RA外有风寒湿邪相感、内有炎热火毒的病因病机,张老师将清热解毒、祛风除湿作为主要治法,用药多选数效兼备之药。

Objective：To analyze ZHANG Minghe＇s medication rules in treatment of rheumatoid arthritis（RA） at active stage by data Mining method. Methods：The effective prescriptions of ZHANG Minghe for treating rheumatoid arthritis at active stage were screened out and put into traditional Chinese medicine inheritance system,so that the frequency of drug usage,combination rules and new prescriptions can be analyzed and found out. Results：A total of 99 effective prescriptions were screened out,containing 69 herbs. In the ＂frequency of drug usage ＂ module,20 herbs used with high frequency were found out,most of which were herbs for clearing heat and removing poison,or driving wind and removing dampness. In the ＂combination rules＂ module,the association rules among the herbs were analyzed,which showed that herbs for clearing heat and removing poison had the highest correlation with herbs for driving wind and removing dampness,followed by dampness- draining herbs. In the ＂New prescription＂ module,it is found that ZHANG Minghe often combined herbs for clearing heat,driving wind and dampness,draining water,promoting blood circulation and warming the interior together,and payed attention to use herbs with similar effects for their mutual reinforcement. Conclusion：Aiming at the pathogen of external wind,coldness and dampness and internal heat and fire,ZHANG Minghe took clearing heat and removing poison,driving wind and removing dampness as the main methods in treatment of RA. In medication,he often used herbs with various effects.