中西医结合治疗晚期胰腺癌重度疼痛疗效观察

Observation of Curative Effect of Combination of Traditional Chinese and Western Medicine on Treatment of Severe Pain in Advanced Pancreatic Cancer

目的 :观察中西医结合治疗晚期胰腺癌重度疼痛的临床疗效。方法 :28例晚期胰腺癌患者按随机数字表法分为治疗组和对照组各14例。对照组给予盐酸羟考酮缓释片和盐酸吗啡注射液控制癌痛,治疗组在对照组的基础上加入中医治疗,两组均以14 d为1个观察周期。14 d后根据两组治疗前后疼痛数字量表(NRS)评分变化判定疗效。结果:治疗后两组NRS评分较治疗前均显著降低,差异有统计学意义(P=0.000);治疗组治疗后NRS评分低于对照组,差异有统计学意义(P=0.014);治疗组总有效率100%,对照组64.29%,治疗组疗效优于对照组,差异有统计学意义(P=0.041)。结论:中西医结合治疗晚期胰腺癌重度疼痛疗效确切。

Objective：To observe the clinical curative effect of combination of traditional Chinese and western medicine on severe pain in advanced pancreatic cancer. Methods ：A total of 28 cases of advanced pancreatic cancer were divided into treatment group and control group by the random number table. The control group was given oxycodone hydrochloride and morphine hydrochloride injection to control cancer pain. The treat-ment group,on basis of the treatments of the control group,was added Chinese medical therapy. The observation period was 14 days. After 14 days,the curative effects of the two groups were evaluated according to the changes of their scores of the numerical rating scale（NRS）. Results：The NRS scores of the two groups after treatment were significantly lower than those before treatment. The difference was statistically significant（P=0.000）. After treatment,the NRS score of the treatment group was lower than that of the control group and the difference was statistically significant（P=0.014）. The total effective rate of the treatment group was100% and the control group was 64.29%. The curative effect of the treatment group was better than that of the control group and the difference was statistically significant（P=0.041）. Conclusion：Combination of traditional Chinese and western medicine has definite curative effect on severe pain in advanced pancreatic cancer.