神经调节素1基因SNPrs2954041多态性与精神分裂症及认知功能的关联研究

Association of neuregulin I gene SNPrs2954041 polymorphisms with schizophrenia and cognitive function

目的探讨神经调节素1（NRG1）基因SNPrs2954041多态性与精神分裂症及认知功能的关系。方法选取70例精神病患者作为观察组，70例健康者作为对照组，检测NRG1基因SNPrs2954041多态性，并对患者的认知功能和神经软体征评分进行评估。结果两组SNPrs2954041多态性基因型和等位基因频率比较差异均有统计学意义（Х^2=35．412、29．341，均P=0．000）。男性患者组与男性对照组之间基因型和等位基因频率的差异有统计学意义（Х^2=24．571、18．391，均P=0．000）。而女性组间的上述结果比较差异也有统计学意义（Х^2==14．145、13．024，均P=0．000）；三组在理解记忆方面差异有统计学意义（F=3．781，P=0．031），三组在数字广度、正确数、错误数、持续错误数、非持续错误数等方面比较差异均无统计学意义（F=0．702、0．125、0．089、0．692、0．113，P=0．498、0．882、0．927、0．512、0．748）。精神分裂症组T／T基因型[（6．79±0．55）分]、T／G基因型[（6．88±0．51）分]和G／G基因型[（6．53±0．39）分]之间神经软体征评分比较差异无统计学意义（F=0．142，P=0．843）。结论NRG1基因SNPrs2954041多态性与精神分裂症存在关联，与精神分裂症患者的认知功能相关。

Objective To study the association of neuregulin 1 （ NRG1 ） gene SNPrs2954041 polymorphisms with schizophrenia and cognitive function. Methods 70 psychiatric patients were selected as observation group, 70 healthy persons were selected as control group. NRG1 gene SNPrs2954041 polymorphism was detected, and the patients＇cognltive function and neurological NSS score were evaluated. Results The differences of SNPrs2954041 polymorphism genotype and allele frequencies between the two groups were statistically significant （Х^2= 35.412,29.341, all P =01000）. The differences in genotype and allele frequencies between the male observation patients and male control group were statistically significant （Х^2= 24.571,18.3 91, all P = 0.000 ）. The differences in genotype and allele frequencies between female the observation patients and female control group were statistically significant （ Х^2= 14. 145,13. 024, all P = 0.000）. The difference of memory understanding among the three groups was statistically significant（F =3. 781 ,P =0. 031 ）. The difference of digit span,correct number, errors number, errors continued number,non- sustained errors number in three groups showed no significant differences（ F = 0. 702,0. 125,0. 089, 0. 692,0.113, P = 0.498,0. 882,0. 927,0.512,0. 748 ）, the difference of neurological soft signs score of T/T geno- type [ （6.79 ± 0.55 ） points ], T/G genotype [ （ 6.88 ±0.51 ） points ] and G/G genotype [ （ 6.53 ±0.39 ） points ] in schizophrenia group was not statistically significant（ F = 0. 142 ,P = 0.843 ）. Conclusion NRG1 gene SNPrs2954041 polymorphism was related to schizophrenia and cognitive function in patients with schizophrenia.