不同剂量地佐辛联合丙泊酚静脉麻醉用于人工流产术的效果评价

Evaluation of different doses dezocine combined with propofol intravenous anesthesia for artificial abortion

目的探讨在人工流产术中应用不同剂量地佐辛联合丙泊酚静脉麻醉的临床效果。方法选取150例行人工流产术者为研究对象，采用数字表法随机分为A、B、C三组，三组在麻醉诱导期均给予地佐辛静脉注射，剂量分别为0．025mg／kg、0．05mg／kg、0．1mg／kg，10min后再缓慢静脉注射丙泊酚，比较三组行人工流产术的临床效果。结果手术期间各个时间段，B组平均动脉压（MAP）、心率（HR）及脉搏血压饱和度（SpO2）较A、C两组稳定，手术安全性较高（tA=6．06、tB=0．88、tc=1．73，PA〈0．05、PB〉0．05、Pc〉0．05）；B组丙泊酚用量[（113．56±18．12）mg]、术后苏醒时间[（6．72±1．69）min]均明显优于A组[丙泊酚用量（150．01±21．45）mg、术后苏醒时间（10．43±3．38）min]，差异均有统计学意义（t=9．17、6．94，均P〈0．05）；B组丙泊酚用量、术后苏醒时间均稍高于C组[丙泊酚用量（110．21±19．32）mg、术后苏醒时间（7．40±1．87）min]，但差异均无统计学意义（t=0．89、1．91，均P〉0．05）；B组不良反应发生率（8．00％）明显低于A组（30．00％），差异有统计学意义（Х^2=2．21，P〈0．05）；B、C两组不良反应发生率差异无统计学意义（P〉0．05）。结论人工流产术中应用剂量为0．05mg／kg的地佐辛联合丙泊酚静脉麻醉临床效果最佳，手术前后各生命指标较为稳定，有效减少丙泊酚用量，缩短手术时间及术后苏醒时间，不良反应少。

Objective To evaluate clinical results of different doses of dezocine combined with propofol in- travenous anesthesia in abortion. Methods 150 patients with routinely abortion were randomly divided into group A, B,C, at induction the patients were given anesthesia dezocine intravenous doses of O. 025mg/kg, 0. 05mg/kg, 0.1 mg/kg, lOmin after slowly intravenous injection of propofol, the clinical results were compared in three groups of artificial abortion. Results Each time during surgery, mean arterial pressure （MAP）, heart rate （HR） and blood pressure pulse saturafion（SpO2 ） indicators in group B were more stable than groups A, C the operations security was higher （ tA = 6.06,tB = 0.88, tc = 1.73, PA 〈 0. 05, PB 〉 0.05, Pc 〉 0.05 ）. Dose of propofol, postoperative recovery time of group B [ （ 113.56 ± 18. 12） mg, （6.72 ± 1.69） mini were significantly better than those in group A [（150.01 ±21.45）mg,（10.43 ± 3.38） mini ,and the differences were statistically significant （t =9.17,6.94,all P 〈 0. 05 ）. The propofol dose, postoperative recovery time in group B were slightly higher those in group C [ （ 1 10.21 ± 19.32 ） mg, （ 7.40 ± 1.87 ） min ], and the differences were not statistically significant （ t = 0.89,1.91, all P 〉 0.05 ）. The incidence rate of adverse reactions of group B （ 8.00% ） was significantly lower than that in A group （30.00%）, and the difference was statistically significant（ Х^2 = 2.21 ,P 〈 0. 05 ）. The incidence rate of adverse reactions in group B, C had no significant difference （ P 〉 O. 05 ）. Conclusion Abortion application dose of 0.05 mg/kg of dezoeine combined with propofol intravenous anesthesia has the best clinical effect, each relatively stable vital signs after surgery, can effectively reduce the dose of propofol, shorten the operation time and postoperative recovery time, and has fewer adverse reactions.