四联疗法根除幽门螺旋杆菌的临床效果观察

Clinical effect observation of quadruple therapy for eradication of Helicobacter pylori

目的观察四联疗法根除幽门螺旋杆菌的临床效果。方法选择某院2010年5月~2013年5月幽门螺旋杆菌阳性患者82例,随机数字分为观察组和对照组,每组41例。观察组用四联疗法（奥美拉唑、阿莫西林、左氧氟沙星、丽珠得乐）治疗,对照组用三联疗法（奥美拉唑、克拉霉素、左氧氟沙星）治疗,疗程均为14 d,治疗结束4周后复查,比较两组根除幽门螺旋杆菌的治疗效果。结果观察组幽门螺旋杆菌根除率为95.12%,明显高于对照组的80.49%（χ2=4.11,P﹤0.05）。结论四联疗法根除幽门螺旋杆菌的临床效果好,值得临床应用推广。

Objective To observe the clinical effect of quadruple therapy for eradication of Helicobacter pylori.Methods From May 2010 to May 2013,82 cases of Helicobacter pylori positive patients were randomly divided into observation group and control group,41 cases in each group.The observation group in the treatment of（quadruple therapy of omeprazole,amoxicillin,levofloxacin,Livzon dele）;control group in the treatment of（triple therapy with omeprazole,clarithromycin,levofloxacin）.The treatment both lasted for 14 days,around check after the end of treatment,compared two groups of eradication Helicobacter pylori treatment.Results The eradication rate of Hpylori in the observation group was 95.12%,significantly higher than that in the control group of 80.49%（χ2= 4.11,P〈0.05）.Conclusion The clinical effect of quadruple therapy for eradication of Helicobacter pylori is good,it is worthy of clinical application.