丹红注射液对不同病情严重程度糖尿病患者血小板活化功能和肾功能的影响

Effect of Danhong injection on platelet activation and renal function in patients with diabetic nephropathy at different severity degree

目的探讨丹红注射液对不同严重程度糖尿病患者血小板活化功能及肾功能的影响。方法根据24h尿蛋白排泄率(UAER)将符合条件的170例2型糖尿病患者分为正常蛋白尿组55例、微量尿蛋白组50例、临床蛋白尿组65例,每组再随机分为观察组和对照组。对照组给予常规降糖、降压、降脂药物治疗,观察组在对照组治疗基础上给予丹红注射液静滴,连用2周。观察各组治疗前后血糖、血脂及血小板活化依赖性颗粒表面膜蛋白(GMP140)、血小板溶酶体颗粒膜蛋白(CD63)的表达和UAER、SCr的变化。结果观察组和对照组治疗前血糖、血脂、GMP-140、CD63、UAER、SCr比较差异均无统计学意义(P均>0.05)。正常蛋白尿组和微量尿蛋白组中观察组治疗后FBG、TG、TC、LDL-C水平均明显低于治疗前(P均<0.05),HDL-C水平均明显高于治疗前(P均<0.05),而对照组仅FBG明显低于治疗前,且观察组治疗后各指标改善情况均明显优于对照组(P均<0.05);临床蛋白尿组中观察组和对照组治疗后FBG、TG、TC、LDL-C、HDL-C均明显改善(P均<0.05),且观察组改善情况均明显优于对照组(P均<0.05)。正常蛋白尿组中观察组和对照组治疗后GMP-140、CD63、UAER、SCr均明显低于治疗前(P均<0.05),但观察组和对照组治疗后上述指标比较差异均无统计学意义(P均>0.05);微量尿蛋白组和临床蛋白尿组中观察组和对照组治疗后GMP-140、CD63、UAER、SCr均明显低于治疗前(P均<0.05),且观察组改善情况明显优于对照组(P均<0.05)。结论丹红注射液可明显降低不同病情严重程度糖尿病患者GMP-140、CD63的表达,抑制血小板活化,减少尿蛋白,改善肾功能,尤其对糖尿病肾病患者疗效更好。

Objective It is to explore the effect of Danhong injection on platelet activation and renal function in patients with diabetic nephropathy at different severity degree. Methods One hundred and seventy patients with type 2 diabetes （T2DM） were selected in the study. All patients were divided into normal proteinuria （Nor- upor） （55 cases） , micro pro- tein urine （Mie-upor） （50 cases） and clinical protein urine （Cli -upor） （65 cases） according to 24h urinary albumin （UAER）. All types were divided randomly into observation group and control group,the control group was treated by conven- tional hypoglyccmic and antihypertensive drugs and the observation group was added with Danhong injection by intravenous drip for 2 weeks. The changes of blood glucose, blood lipid, GMP - 140, CD63, UAER and SCR were observed before and after treatment. Results There was no significant differences in the level of blood glucose, blood lipid ,UAER, SCR, GMP - 140 and CD63 between the two groups before treatment（ P 〉 0.05 ）. The level of FBG, HbA1C, TG, TC and LDL - C significantly decreased and the level of HDL - C increased significantly in the observation groups of Nor - upor and Mic - upor, while only the level of FBG decreased significantly in the control group. All the improvements of indicators in the observation group were better than those in the control group （ P 〈 0.05 ）. The index significantly improved in two groups of Cli - upor after treatment, but all the indicators in the observation group were significantly higher than those in the control group, and there was statistical significance （P 〈0.05）. The levels of UAER, SCr, GMP - 140 and CD63 in the two groups of Nor - upor significantly de- creased after treatment, but there was no significant differences. The level of UAER, SCr, GMP - 140 and CD63 in two groups of Mic - upor and Cli - upor significantly decreased after the treatment, but the indicators in the observation group were significantly higher than those in the control group,there was statistical significance （P 〈 0.05）. Conclusion Danhong injec-tion could significantly decrease the expression of GMP - 140 and CD63, inhibit platelet activation,reduce urinary protein and improve renal function in patients with diabetic nephropathy.