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阻塞性睡眠呼吸暂停与肿瘤的关系 被引量：3

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摘要 流行病学调查表明,患有阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)的病人较普通人而言有更高的癌症风险和癌症相关死亡率。近年来许多研究也揭示了OSA的两个关键事件,即间断性缺氧(intermittent hypoxia,IH)和/或睡眠片段化(sleep fragmentation,SF)对肿瘤的生长起到促进作用的这一事实。本文旨在通过归纳现有的间断性缺氧和/或睡眠片段化促进肿瘤发生/发展的分子机制,为肿瘤的预防和治疗提供思路和方向。
作者 李斯言 潘燕 李学军
机构地区 北京大学基础医学院药理学系
出处 《生理科学进展》 CAS CSCD 北大核心 2016年第3期211-214,共4页 Progress in Physiological Sciences
基金 国家自然科学基金(30772571 30901815 81270049)资助课题
关键词 阻塞性睡眠呼吸暂停 间断性缺氧 睡眠片段化 肿瘤 生长
分类号 R730 [医药卫生—肿瘤]
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参考文献20

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二级参考文献13

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生理科学进展
2016年 第3期

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