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MicroRNA-432与TGF-β1在风湿性心脏病合并心房颤动患者中的表达 被引量：5

Expression of microRNA-432 and TGF-β1 in atrium of patient with rheumatic heart disease and atrial fibrillation
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摘要 心房颤动（简称房颤）是临床上最为常见的心律失常,具有高致残率和高致死率特点。微小RNA（microRNA,miRNA）是新发现的一类高度保守的内源性非编码小RNA,是基因表达转录后调节的重要分子,能够通过与靶mRNA特异性的碱基配对引起靶mRNA的降解或者抑制其翻译,从而对基因进行转录后表达的调控。 We observed the expression of miRNA-432 and TGF-β1in the atrium of patients with rheumatic heart disease and atrial fibrillation.The results showed the down-regulation of miRNA-432 and up-regulation of TGF-β1in the atrium,which was related to the occurrence and maintenance of atrial fibrillation in rheumatic heart disease.
作者 龙秀环 徐新 张社兵 唐良秋 范文茂 张桂莲 何凤屏
机构地区 粤北人民医院心血管内科
出处 《临床心血管病杂志》 CAS CSCD 北大核心 2016年第6期633-636,共4页 Journal of Clinical Cardiology
关键词 风湿性心脏病 心房颤动 miRNA-432 转化生长因子-Β1 心肌纤维化 心肌重构 rheumatic heart disease atrial fibrillation MiRNA-432 transfer growth factor-β1 myocardial fibrosis myocardial remodeling
分类号 R541.2 [医药卫生—心血管疾病]
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参考文献18

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二级参考文献12

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临床心血管病杂志
2016年 第6期

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