成纤维细胞生长因子受体2在胃癌中的研究进展

Research Progress of FGFR2 and Gastric Cancer

成纤维细胞生长因子受体2(FGFR2)作为酪氨酸激酶受体家族成员之一,在一系列正常细胞活动信号转导中起着重要的作用,其异常活化会导致多种肿瘤的发生及进展。FGFR2与胃癌的临床类型、临床分期、淋巴结及远处脏器转移密切相关。针对FGFR2的抑制剂对FGFR2高表达胃癌细胞系及建立的移植瘤模型中的肿瘤细胞有明显的抑制作用。因此,以FGFR2为分子靶点治疗FGFR2高表达胃癌,将为胃癌的分子靶向治疗开辟新路径。

Fibroblast growth factor receptor 2 （ FGFR2 ） is a member of the receptor tyrosine kinase （RTK） family and plays an important role in signal transduction pathways of regulating a number of cellular functions,and the aberrant or oncogenie activation of FGFR2 is closely related to the occurrence and the development of various tumors. FGFR2 expression is associated with the pathological type, clinical stage, lymph node and distant metastasis of gastric cancer. FGFR2 inhibitor can signifieantly inhibit the proliferation of FGFR2-amplified gastric cancer cells and xenografts, suggesting that FGFR2 is a therapeutic target for FGFR2 gene-amplified gastric cancer.