抗菌肽及其模拟物的临床应用研究进展

Current progress in clinical research of antimicrobial peptides and peptidomimetics

抗菌肽,作为一种新型的抗生素替代药物,近年来得到了极大关注。本文概述了抗菌肽及其模拟物的抗菌特性及优势特点,着重阐述了其临床研究进展和临床应用面临的挑战。抗菌肽具有不同于传统抗生素的独特抗菌机制,能够杀灭多重耐药菌且不易诱导产生抗药性,数十种抗菌肽已进入了临床试验阶段,但是毒性作用、不稳定性及成本昂贵使其临床应用受到限制。针对上述缺陷,研究者尝试合理改造抗菌肽的结构,并着手研发抗菌肽模拟物。相信在未来,抗菌肽及其模拟物会在对抗耐药菌方面发挥重要的作用。

As potential alternatives to conventional antibiotics, antimicrobial peptides have attracted great attention in recent years. This review provides an overview of their characteristics and mechanisms of action, summarizes the current progress in clinical research and challenges in clinical utility. Antimicrobial peptides display robust activity against a wide variety of pathogens, including multidrug resistant bacteria, and are less susceptible to resistance development. Dozens of antimicrobial peptides are currently in various stages of clinical trials. However, some intrinsic drawbacks limit their clinical utility： toxicity, stability and manufacturing costs. Researchers have tried to modify the structure of antimicrobial peptides and worked on developing peptidomimetics. It is believed that antimicrobial peptides and peptidomimetics will play an important role against multidrug resistant bacteria in the future.