每日限食与隔日限食对2型糖尿病的预防作用

Daily calorie restriction and alternate day fasting for type 2 diabetes prevention

生活方式干预是防治2型糖尿病的重要手段。限食疗法作为生活方式干预的手段之一业已成为近年研究的热点。隔日限食操作简单，患者依从性好，在减轻糖尿病前期患者的体重，减少内脏脂肪含量，降低胰岛素水平，改善胰岛素敏感性和保护非脂肪组织方面与每日限食相当。然而，二者对空腹血糖的影响并不明显。即便如此，目前仍普遍认为，糖尿病前期患者可以采用每日限食，尤其是隔日限食，达到预防2型糖尿病的目的。

Lifestyle intervention is one of the important strategies for the prevention of type 2 diabetes. Recently, caloric restriction regimen has become a hot topic as one of the cornerstone of lifestyle intervention. The alternate day fasting regimen is simple, and increases the patient compliance. Both daily calorie restriction and alternate day fasting regimen can reduce body-weight significantly in pre-diabetes subjects, and reduce the visceral fat mass and the fasting insulin levels, and improve the insulin sensitivity, as well as maintain the lean mass, though the effect on fasting blood glucose was not significant. Nevertheless, the most recent studies have demonstrated that daily calorie restriction,in particular, alternate day fasting regimens can be effective in individuals with pre-diebates in order to prevent type 2 diabetes.