铜L-色氨酸配合物的合成与表征

Synthesis and Characterization of Copper L-Tryptophan Complex

利用液相反应合成法制得了铜(Ⅱ)和L-色氨酸的配合物,结合元素分析、差示扫描量热与热重分析联用、粉末X射线衍射法以及红外光谱实验手段对该配合物进行表征。结果表明,1个铜离子能够与2个L-色氨酸分子通过侧链氨基上的氮原子和羧基上的氧原子配合,形成稳定的配合物。利用太赫兹时域光谱法获得了室温条件下铜-L-色氨酸配合物在低频波段的光谱特征,并结合密度泛函理论计算对太赫兹光谱进行分析。该配合物在太赫兹波段的吸收对应于分子整体的振动,涉及吲哚环和侧链的扭曲振动。研究结果有助于深入了解铜离子与氨基酸的相互作用,以及铜离子在复杂生物体中所起的作用。

A copper（ Ⅱ） L-tryptophan complex was synthesized in aqueous solution and characterized by element analysis,differential scanning calorimetry and thermogravimetry,powder X-ray diffraction and Fourier transform infrared spectroscopy. The results showed that the compound had a good stability. A copper ion could combine with two L-tryptophan molecules through the nitrogen of the amine group and one oxyen of the carboxyl group. The low-frequency vibrational spectrum was measured by terahertz time-domain spectroscopy（ THz- TDS） at room temperature. Density functional theory was employed to calculate the low-frequency vibrational properties. The result indicated that THz absorption spectrum mainly reflected the collective vibrational modes of the whole molecules including the distortional vibration of indole ring and the side chain. The studies are helpful to understand the interaction of copper ion with amino acid and the role of the copper ion in complex organisms.