血小板相关参数在肺结核诊断中的应用研究

The Application of Platelet-Related Parameters in Diagnosis of Pulmonary Tuberculosis

目的探讨血小板参数在肺结核患者的诊断与治疗中的意义。方法分别定量检测120例肺结核患者(活动期65例和非活动期55例)、100例肺炎患者(急性期50例和慢性期50例)和100例健康对照组的血小板压积(PCT)、血小板分布宽度(PDW)和血小板平均体积(MPV)等血小板指标。结果 PLT、PCT、PDW(血小板平均体积分布宽度)、MPV在结核活动期组分别为(276.84±127.30)×109/L、(0.25±0.11)%、(11.74±2.85)%、(9.16±1.27)f L,在结核非活动期组分别为(195.91±71.53)×109/L、(0.18±0.06)%、(12.59±3.35)%、(9.37±1.67)f L,在肺炎急性期组分别为(239.74±104.44)×109/L、(0.19±0.07)%、(12.39±0.79)%、(8.23±1.17)f L,在肺炎慢性期组分别为(207.22±68.83)×109/L、(0.17±0.06)%、(12.30±1.02)%、(8.43±0.85)f L,健康对照组分别为(207.65±37.90)×109/L、(0.19±0.03)%、(12.07±1.34)%、(8.79±0.85)f L,肺结核活动期组PLT、PCT、MPV较急性肺炎组和健康组均有显著增加(P<0.05),肺结核活动期组较非活动期组PLT、PCT均有显著增加(P<0.05),MPV无显著变化。结论 PLT、PCT和MPV可作为临床医生辅助诊断肺结核及判断肺结核是否处于活动期的参考指标。

Objective To study the significance of platelet related parameters in diagnosis and treatment of pulmonary tuberculosis. Methods Platelet distribution width （PDW）, mean platelet volume（MPV） and plateletcrit （PCT） were detected in 120 pulmonary tuberculosis patients （Active cases 65 and 55 cases of non-active）, 100 pneumonia patients （acute phase 50 cases and chronic 50 cases）and 100 healthy controls before treatment. Results PLT, PCT, PDW and MPV were （ 195.91 ± 71.53 ）× 109/L, （0. 18 ± 0.06） %, （ 12. 59 ±3.35 ） t, （9.37± 1.67）% respectively in the inactive tuberculosis group, （207.22±68.83） ×109/L, （0. 17 ±0. 06）%, （12. 30 ± 1.02） /L, （8.43± 0.85）% respectively in the chronic phase of pneumonia group, （276.84 ± 127.30） × 109/L, （0.25 ±0.11）%, （11.74 ±2.85） fL, （9.16 ±1.27）% respectively in the active tuberculosis group and （207.65 ± 37.90） × 109/L, （0. 19 ± 0.03 ） %, （ 12.07 ± 1.34） fL, （8.79 ± 0. 85 ） % respectively in the healthy control group. When compared PLT, PC-T, MPV between active tuberculosis group and acute pneumonia group and the healthy group, all value were significantly increased （P 〈0.05）. PLT, PCT were significantly increased （P 〈 0.05） in active tuberculosis group than that in the inactive group. MPV had no significant differences. Conclusion Detection of PLT, PCT, and MPV can be a valuable tool for clinician in diagnosis of tuberculosis. It can also provide helpful reference to determine whether patients are in active phase.