消旋卡多曲联合蒙脱石散治疗小儿轮状病毒肠炎患者临床研究

Clinical Study on Racecadotril Combined with Montmorillonite Powder in Treatment with Infantile Rotavirus Enteritis

目的探讨消旋卡多曲联合蒙脱石散治疗小儿轮状病毒性肠炎的临床效果。方法将72例轮状病毒性肠炎患儿随机分成两组,每组36例。对照组给予蒙脱石散,观察组在对照组的基础上加用消旋卡多。对两组临床疗效及C-反应蛋白(CRP)和血沉(ESR)水平变化进行观察。结果观察组呕吐消失时间、腹痛消失时间、止泻时间及大便常规正常时间均明显短于对照组,差异具有统计学意义(P<0.05);观察组治疗总有效率为94.4%,明显高于对照组的75.0%,差异有统计学意义(P<0.05)。治疗后两组CRP和ESR水平显著降低,观察组CRP和ESR水平为7.2±2.9mg/L、11.2±3.6mm/h,均显著性低于对照组的13.9±3.5mg/L、17.6±4.4 mm/h,差异有统计学意义(P<0.05)。结论消旋卡多曲联合蒙脱石散治疗小儿轮状病毒性肠炎,可快速的改善患儿临床症状,降低CRP和ESR水平。

Objective To investigate the efficacy of racecadotril combined with montmorillonite powder on children rotavirus enteritis. Methods A total of 72 children with rotavirus enteritis were selected and randomly divided into two groups, 36 cases in each group. Patients in control group were given montmorillonite powder only, and patients in observation group were given racecadotril plus montmorillonite powder. The clinical efficacy, C-reactive protein （CRP） and erythrocyte sedimentation rate （ESR） level of two groups were observed. Results The vomiting disappearance time, stomach ache disappearance time, diarrhea time, and stool becoming normal time of observation group were significantly shorter than that in control group （P 〈0.05 ） ; The total effective rate of observation group was 94.4%, which was significantly higher than that in control group （75.0%） （P 〈 0.05 ）. After treatment, the CRP and ESR levels of two groups were significantly decreased. CRP and ESR levels of observation group were 7.2 ±2.9 mg/L, 11.2 ± 3.6mm/h, which were significantly lower than 13.9 ±3.5 mg/L, 17.6 ± 4.4 mm/h in control group （ P 〈 0.05 ）. Conclusion Racecadotril combined montmorillonite powder can effectively treat rotavirus enteritis in children, and reduce the CRP and ESR levels.