肝细胞生长因子、碱性成纤维细胞生长因子及血管源性生长因子在成人烟雾病不同阶段的变化

Changes of HGF, FGF and VEGF in different pathological stages of adult moyamoya disease

目的 探讨成人烟雾病不同阶段中肝细胞生长因子（HGF）、碱性成纤维细胞生长因子（b-FGF）及血管源性生长因子（VEGF）的变化。方法 回顾性分析2013年11月～2014年12月江西省人民医院（以下简称“我院”）神经内科住院的行全脑血管造影检查确诊为烟雾病的41例患者临床资料,根据Suzuki分期,8例患者为早期（Suzuki分期1～2期）,17例为中期（Suzuki分期3～4期）,16例为晚期（Suzuki分期5～6期）,同时选择在我院诊治的40例脑动脉粥样硬化患者为阳性对照,另选择我院20例健康体检者为正常对照。采用酶联免疫吸附法（ELISA法）检测上述人群血清中HGF、b-FGF及VEGF浓度。结果 烟雾病早、中、晚期患者的HGF与动脉粥样硬化患者、健康人比较,差异有统计学意义（P〈0.05）。烟雾病晚期患者b-FGF与动脉粥样硬化患者、健康人比较,差异有统计学意义（P〈0.05）烟雾病早期患者VEGF与动脉粥样硬化患者、健康人比较,差异有统计学意义（P〈0.05）。结论 烟雾病的发生发展过程HGF、b-FGF及VEGF均有参与,但三者作用并不相同,HGF可能在烟雾病整个发生发展过程中均发挥作用,而b-FGF可能在烟雾病晚期发生发展中发挥了作用,VEGF则可能在烟雾病早期发生发展中发挥了作用。

Objective To investigate the changes of hepatocyte growth factor （HGF）, basic fibroblast growth factor （b- FGF） and blood vessels origin of growth factor （VEGF） in the different pathological stages of adult moyamoya disease （MMD）. Methods The clinical data of 51 patients with MMD were retrospectively analyzed from November 2013 to December 2014 in the People＇s Hospital of Jiangxi Province, all patients received examinations of Digital Subtraction Angiography, according to Suzuki diagnostic criteria, 8 patients were early stage （Suzuki 1-2 stage）, 17 cases were middle stage （Suzuki 3-5 stage）, 16 cases were late stage （Suzuki 5-6 stage）. At same time, 40 patients with cerebral atherosclerosis were selected as positive control, and 20 normal people were selected as normal control. HGF, b-FGF and VEGF concentration in serum measured by using enzyme-linked immunosorbent （ELISA）. Results HGF in the early, middle and late stage of MMD patients were compared to atherosclerosis patients and healthy persons, the differences were statistically significant （P 〈 0.05）. b-FGF in the late stage of MMD were compared with atherosclerosis patients and healthy persons, the differences were statistically significant （P 〈 0.05）. VEGF in the early stage of MMD were com- pared with atherosclerosis patients and healthy persons, the differences were statistically significant （P 〈 0.05）. Conclusion HGF, b-FGF and VEGF are involved in the development process of MMD, HGF may play a role in the whole development process in MMD, b-FGF may play a role at the late MMD developing, and VEGF may play a role in early development in MMD.