Krüppel样因子5的生物学功能及其与肿瘤发生的关系

The Biological Function of Krüppel-like Factor 5 and Its Association with Cancer Occurrence

Krüppel样因子5(Krüppel-like factor 5,KLF5)是一类进化保守的锌指型转录因子,它能调控下游众多靶基因的表达。KLF5参与细胞增殖、分化和凋亡等细胞生物学过程。翻译后修饰对KLF5的稳定性和发挥作用产生影响,而KLF5与非编码RNA之间也存在相互作用。越来越多的研究表明,KLF5异常表达于人类多种肿瘤(包括结直肠癌、乳腺癌、前列腺癌等)。KLF5不仅参与肿瘤的发生,而且与患者预后相关。有趣的是,KLF5在一部分肿瘤中的功能表现为环境依赖性,而且翻译后修饰和性激素水平影响其功能的发挥。鉴于KLF5在肿瘤中的重要作用,它被认为是一个潜在的肿瘤诊断标志物和肿瘤治疗新靶点。

Kruppel-like factor 5 （KLF5） is an evolutionarily conserved zinc finger transcrpfion factor that regulates the expressions of many downstream genes. It takes part in the regulations of proliferation, differentiation and apoptosis. Post-translational modifications influence the stability of KLF5 and its roles. In addition, there are interactions between KLF5 and non-coding RNAs （ncRNAs）. Increasing researches showed that the expression of KLF5 was frequently abnormal in human cancers including colorectal cancer, breast cancer, prostate cancer and so on. KLF5 involves in carcinogenesis and is associated with prognosis of patients with cancer. The function of KLF5 reveals context-dependent in some types of cancer. Post-translational modifications and sex hormone always affect its function. Due to its significant roles in human cancers, KLF5 may be a potential diagnostic biomarker and therapeutic target for human cancers.