间充质干细胞在肿瘤微环境中作用的研究进展

Research Progress of Mesenchymal Stem Cells in Tumor Microenvironment

干细胞的发现及其功能的研究是近年来医学乃至整个生命科学领域的研究热点。干细胞因其具有高度自我更新和多向分化潜能,是细胞移植的首选靶细胞。间充质干细胞具有较弱的免疫原性使其成为肿瘤生物治疗的首选载体,被广泛用于抗肿瘤的研究。但是,目前间充质干细胞和肿瘤细胞的相互关系已引起学者的关注,大量实验结果表明间充质干细胞和肿瘤的关系存在两面性,有研究证实干细胞能够抑制肿瘤细胞生长,但亦有研究表明干细胞能够促进肿瘤的生长和转移,甚或干细胞发生恶性转化,获得了肿瘤细胞的相关生物学特性。其临床应用的安全性和实用性也有待于进一步的验证。本文对骨髓间充质干细胞在肿瘤微环境中作用的研究进展作一简要综述。

The research of the discovery of stem cells and its function is the research hotspot in the medicine and the field of life science in recent years. Because of its high self-renewal and multi-directional differentiation potential,stem cells is the first choice for cell transplantation target cells. Mesenchymal stem cells with weak immunogenicity makes it a tumor biological treat-ment of choice for the carrier,is widely used in research of antitumor. But the current relationship between mesenchymal stem cells and tumor cells has aroused the attention of scholars. A large number of experimental results show that the existence of mesenchymal stem cells and tumor re-lations between two sides. Studies have confirmed that stem cells can inhibit the growth of tumor cells,but also studies have shown that stem cells can promote tumor growth and metastasis,or stem cells undergo malignant transformation,obtain the related biological characteristics of tumor cells. Safety and practicability of its clinical application are subject to further validation. In this paper,we review the research progress of the filling bone marrow stromal stem cells in the tumor microenvironment.