35例肥胖/超重儿童与非酒精性脂肪性肝病相关因素分析

Correlation Factors Analysis of 35 Cases of Obesity/Overweight Children with Nonalcoholic Fatty Liver Disease

目的探讨肥胖/超重儿童与非酒精性脂肪性肝病（NAFLD）发病的相关因素,以期减少NAFLD的发生。方法随机选择2012年1月~2015年11月儿童保健门诊正常查体3~10岁肥胖/超重儿童35例,空腹采血查肝功、血糖、血脂、体质指数（BMI）、肝胆彩超等,采集平素生活习惯信息,并与35例正常儿童结果进行统计学分析。结果两组间肥胖家族史比较差异非常显著,糖尿病家族史、血脂、血糖异常率比较差异均无显著性,而两组间谷丙转氨酶（ALT）异常率、患儿腹围比较差异有统计学意义（P〈0.05）。结论儿童肥胖/超重与遗传因素有关,不良饮食习惯为其诱因之一,与静态生活方式相关性不大;非侵入性诊断手段为早期诊断NAFLD提供依据,ALT检测可作为筛查指标之一。

Objective To explore the correlation factors of 35 cases of obesity /overweight children with nonalcoholic fatty liver disease,in order to reduce the incidence of NAFLD. Methods From January 2012 to November2015,35 cases of overweight or obese children（ 3 ~ 10 year old） in the hospital were enrolled randomly. Fasting blood check liver function,blood sugar,serum lipid levels,body mass index（ BMI）,liver and gallbladder ultrasound were measured,and their usual habits information was collected,then the statistical analysis were conducted compared with 35 cases of normal children. Results Family history of obesity were significantly different between the two groups of children（P〈0. 05）. Family history of diabetes,blood lipids,blood glucose abnormality rate were not significantly different between the two groups（P〈0. 05）. Waist circumference and abnormal rate of ALT were significantly different between the two groups（P〈0. 05）. Conclusion Childhood obesity / overweight has a relation with genetic factors,and poor eating habits is one of the incentives,with little correlation to the static lifestyle; Non-invasive diagnostic tools can provide some evidence for the early diagnosis of NAFLD,ALT can be used as one of the indexes for screening.