托吡酯预防偏头痛发作研究进展

Review of Research Progress on Topiramate in Migraine Prevention

目的综述并分析托吡酯用于临床偏头痛预防治疗的疗效及安全性,探讨其最新临床研究进展。方法以"托吡酯""偏头痛""预防"为关键词检索知网、万方数据库,共检索到可用目标文献100余篇,从中选择关联性较强的23篇文献进行综述分析。结果临床用于偏头痛预防治疗的方法、药物很多,如曲坦类药物、抗抑郁药物、β-受体阻断剂、钙离子拮抗剂、非甾体类抗炎药物及5-羟色胺受体激动剂等,均在有效预防偏头痛方面具有一定的临床价值,但不同药物作用机制不同,药物的安全性存在显著统计学差异。临床大量数据调查分析结果显示,托吡酯在偏头痛预防治疗方面具有显著统计学意义(P<0.05)。结论既往研究通过设计对照试验,应用统计学方法探讨了托吡酯用于临床偏头痛预防治疗的疗效及安全性。

Objective To review and analyze the clinical efficacy and safety of topiramate for migraine prevention, and to investigate the latest clinical research progress. Methods ＂Topiramate＂＂migraine＂＂prevention＂ were chosen as the key words to search in CNKI and Wanfang database. More than 100 articles were available and 23 with close correlation were chosen as the target objective. Results It was found that there were many clinical treatment methods and drugs for migraine prevention, e. g., the most frequently used in clinic triptans, antidepressants, 15- receptor blockers, calcium antagonists, non- steroidal anti- inflammatory drugs and serotonin receptor agonists, which were effective in the prevention of migraine and had some clinical value, but they also had different mechanism, and the safety of the drugs had significantly statistical difference. A large number of clinical data analysis showed that the mobility of topiramate had sig- nificant statistical significancein migraine prevention treatment（ P 〈 0.05）. Conclusion Previous studies explore the efficacy and safety of topiramate for migraine prevention by designing controlled trial and the statistical methods.