区域性腹膜后减压低位引流与开腹引流术治疗急性重症胰腺炎的临床对照研究

Clinical Effect of Severe Acutepancreatitis Treated With Regional Low Pressure Retroperitoneal Drainage and Open Drainage

目的对比分析区域性腹膜后减压低位引流与开腹引流术治疗急性重症胰腺炎的临床效果。方法 35例急性重症胰腺炎患者均为我院2012-2015年收治的病例,将患者分为两组,腹膜后组18例,采用区域性腹膜后减压低位引流、开腹组17例采用开腹引流治疗。结果腹膜后组患者的并发症情况与开腹组比较差异无统计学意义（P〉0.05）。两组术后14 d TNF-α、IL-6、CRP水平均较术前降低,腹膜后组术后14 d的TNF-α、IL-6、CRP水平低于开腹组,差异有统计学意义（P〈0.05）。腹膜后组患者的手术时间、平均住院时间均短于开腹组,腹膜后组的平均住院费用少于开腹组,两组差异有统计学意义（P〈0.05）。结论区域性腹膜后减压低位引流治疗急性重症胰腺炎患者疗效确切,可有效降低患者的TNF-α、IL-6、CRP等炎症指标水平,缩短手术时间及平均住院时间,减少住院费用。

Objective To compare the effect of severe acutepancreatitis treated with regional low pressure retroperitoneal drainage and open drainage. Methods 35 cases of severe acute pancreatitis patients were selected from 2012 to 2015 in our hospital, they were divided into two groups, the retroperitoneal group of 18 cases was treated with regional low pressure retroperitoneal drainage, the laparotomy group of 17 cases was treated with open drainage. Results There were no significant difference in the complications between two groups（P〈0.05）. Two groups 14 days after TNF-α, IL-6, CRP levels were lower than before surgery, the retroperitoneal group after 14 days of TNF-α, IL-6, CRP levels were lower than the Laparotomy group, the difference was statistically significance（P〈0.05）. The surgery time, the average length of stay of the retroperitoneal group were shorter than the laparotomy group, the average cost of hospitalization was less than the laparotomy group, the difference was statistically significant（P〈0.05）. Conclusion After retroperitoneal regional low pressure drainage therapy for severe acute pancreatitis patients with definite effect, can effectively reduce the patient＇s TNF-α, IL-6, CRP and other inflammatory markers levels, shorten the operation time and the average length of stay, reduce hospital costs.