斑马鱼在中药毒性靶器官研究中的进展

Zebrafish used in toxic target organ studies of Chinese herbs

该文介绍了斑马鱼模型的特点及其在中药毒性靶器官研究中的应用,重点介绍了在急性毒性、肝脏毒性、心血管毒性、肾脏毒性和神经毒性研究等方面的应用,系统分析了斑马鱼这一新型模式动物在中药毒性靶器官研究中的优势及其独特价值,以期为推动中药毒性研究与安全性评价提供新的思路与方法。

In this review,we discuss the advantages of zebrafish models and introduce their applications in target organ toxicity studies of Chinese herbs,especially for acute toxicity,hepatotoxicity,cardiovascular toxicity,kidney toxicity and neurotoxicity tests. The advantages and particular value of zebrafish in toxic target organ studies of Chinese herbs are highlighted. This new vertebrate model may become a powerful tool for toxicity studies and safety assessment of Chinese herbs.