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二苯环丙烯酮治疗12例严重斑秃的疗效观察 被引量：2

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摘要 斑秃是一种突发的局限性斑片状脱发，严重者可形成全秃甚至普秃，多采用局部及系统性应用糖皮质激素治疗，外用毛囊刺激生长剂，辅以免疫调节剂等治疗，但对于那些病程长、反复发作、斑秃面积大的患者往往疗效不佳，且长期使用激素治疗易出现副作用及药物依赖性。
作者 陈琇 程波
机构地区 福建医科大学临床技能教学中心
出处 《福建医科大学学报》 北大核心 2016年第2期138-140,共3页 Journal of Fujian Medical University
关键词 酮类 聚丙烯类 苯 斑秃 秃发 投药 局部
分类号 R758.71 [医药卫生—皮肤病学与性病学]
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参考文献13

  • 1巩毓刚,赵莹,张小婷,叶艳婷,杨建,章星琪.局部免疫法治疗重型斑秃的疗效及作用机制分析[J].中山大学学报（医学科学版）,2012,33(2):216-222. 被引量：19
  • 2Hull S, Norris J. Diphencyprone in the treatment of long- standing alopecia areata[J]. Br J Dermatol, 1988, 119(3) 367-374.
  • 3王博,杨淑霞.自身免疫在斑秃发病机制中的作用[J].临床皮肤科杂志,2010,39(10):670-672. 被引量：16
  • 4Messenger G, Mc Killop J, Farrant P, et al. British Associa- tion of Dermatologists guidelines for the management of alo- peciaareata[J]. Br J Dermatol, 2012,166(5):916-926.
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  • 6Aghaei S. Topical immunotherapy of severe alopecia areata with diphenylcyclopropenone (DPCP) experience in an Irani- an population[J]. BMCDermatology, 2005,5(1):6.
  • 7Hunter N, Shaker O, Marei N. Diphencyprone and topical ta- crolimus as two topical immunotherapeutic modalities Are they effective in the treatment of alopecia areata among Egyp tian patients? A study using CD4, CD8 and MHC ]l as mark- ers[J]. J Eur Acad Dermatol Venereol, 2011,22(1) :2 10.
  • 8张琼翔,吴云,李秉煦.二苯环丙烯酮治疗斑秃16例疗效观察[J].中国皮肤性病学杂志,2012,26(5):407-409. 被引量：6
  • 9Ohlmeier M C, Traupe H, Luger T A, et al. Topical immu notherapy with diphenylcyclopropenone of patients with alope- cia areata - a l.arge retrospective study on 142 patients with a self-controlled design [J]. J Eur Acad Dermatol Venereol , 2012,26(4) : 503-507.
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二级参考文献38

  • 1钱戌春,黄月珍.二硝基氯苯(DNCB)免疫疗法治疗经验[J].新疆医科大学学报,2006,29(10):968-970. 被引量：3
  • 2Barahmani N,Schabath MB,Duvic M,et al.History of atopy or autoimmunity increases risk of alopecia areata[J].J Am Acad Dermatol,2009,61(4):581-591.
  • 3Ito T,Tto N,Bettermann A,et al.Collapse and restoration of MHC class-Ⅰ-dependent immune privilege:exploiting the human hair follicle as a model[J].Am J Pathol,2004,164(2):623-634.
  • 4Dan Wasserman,Daniela Araucaria Guzman-Sanchez,Kimberly Scott,et al.Alopecia areata[J].International Journal of Dermatology,2007,46(2):121-131.
  • 5Trautman S,Thompson M,Roberts J,et al.Melanocytes:a possible autoimmune target in ahpecia areata[J].J Am Acad Dermatol,2009,61(3):529-530.
  • 6Ralf Paus,Brian J,Nickoloff,et al.A‘hairy'privilege[J].Trends in Immunology,2005,26(1):32-40.
  • 7Gilhar A,Landau M,Assy B,et al.Melanocyte-associated T cell epitopes can function as autoantigens for transfer of alopecia areata to human scalp explants on Prkdc(scid)mice[J].J Invest Dermatol,2001,117(6):1357-1362.
  • 8Gilhar A,Kam Y,Assy B,et al.Alopecia areata induced in C3H/HeJ mice by interferon-gamma:evidence for loss of immune privilege[J].J Invest Dermatol,2005,124(1):288-289.
  • 9Ito T,Ito N,Bettermaan A,et al.Collapse and restoration of MHC class-Ⅰ-dependent immune privilege:exploiting the human hair follicle as a model[J].Am J Pathol,2004,164(2):623-634.
  • 10Freyschmidt-Paul P,McElwee KJ,Hoffmann R,et al.Interferongamma-deficient mice are resistant to the development of alopecia areata[J].Br J Dermatol,2006,155(3):515-521.

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二级引证文献6

福建医科大学学报
2016年 第2期

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