肝X受体与炎症的关系

Relationship Between Liver X Receptor and Inflammation

肝X受体(Liver X Receptor,LXRs)属于核受体超家族成员,在转录调控脂质代谢中起重要作用。LXRs通常与视黄酸受体(RXRs)结合形成异二聚体,作用于靶基因的LXR反应元件从而调节靶基因的表达,可被多种配体激活。近来的研究表明巨噬细胞上炎症信号和LXRs信号之间存在一定联系,合成的LXRs配体能阻止炎性基因的表达,抑制炎症的发生。鉴于LXRs整合了炎症和脂质代谢调节信号,LXRs有望成为治疗代谢和炎症信号的分子靶标。本文就此作出综述。

Liver X receptor is a member of the nuclear receptor superfamily （ LXRs）,Play an important role in lipid metabolism and transcriptional regulation.It is commonly associated with retinoic acid receptor （RXRs） to form an ISO two polymer, which acts on the LXR response element of the target gene to regulate the expression of the target gene, which can be activated by a variety of ligands. Recent studies have indicated that there is a link between the inflammatory signal and LXRs signal in macrophages. The synthesis of LXRs ligand can prevent the expression of inflammatory genes and inhibit the occurrence of inflammation. In view of LXRs integration of inflammation and lipid metabolism regulation signal, LXRs is expected to be a molecular target for the treatment of metabolic and inflammatory signals. This article makes a summary.