摘要
为评价山茱萸总萜对2型糖尿病的降血糖作用,对db/db糖尿病小鼠每日灌胃给予25,50,100 mg/kg山茱萸总萜共10周,每2周眼眶采血测定空腹血糖1次。于末次给药24 h后采血测定空腹血糖、胰岛素(Ins)、糖化血清蛋白(GSP)、总胆固醇(TC)、三酰甘油(TG)。给药第8和10周分别进行葡萄糖和淀粉糖耐量试验。结果显示,给药4周后,山茱萸总萜各剂量组db/db小鼠的空腹血糖有明显降低(P<0.05)。给药10周后,山茱萸总萜25,50,100 mg/kg组db/db小鼠血清中TC、TG水平显著降低(P<0.05),血清糖化蛋白水平明显降低(P<0.05),db/db小鼠的葡萄糖耐量和灌胃淀粉糖耐量也有明显改善(P<0.05)。研究结果提示,山茱萸总萜可调节体内糖、脂等代谢过程,对糖尿病具有一定的治疗作用。
To investigate the hypoglycemic effects of terpenes from Fructus Corni(TFC)on type 2 diabetes mellitus, the db/db diabetic mice were intragastrically administered with 25, 50, 100 mg/kg of TFC for 10 weeks. The fasting blood glucose, insulin(Ins), glycosylated serum protein(GSP), total cholesterol(TC)and triglyceride(TG)levels were determined. At weeks 8 and 10, intraperitoneal injections of glucose and gavage starch tolerance tests were performed, respectively. The db/db mice showed obvious obesity. Each dose of TFC could significantly reduce the body weight of db/db mice(P〈 0. 05). After 4 weeks of administration, all doses of TFC significantly reduced the fasting blood glucose of db/db mice(P〈 0. 05). The serum TC, TG levels were also significantly decreased in the TFC middle- and high-dose groups(P〈 0. 05). In addition, middle- and high-dose of TFC could significantly reduce the level of GSP. Middle- and high-dose of TFC also significantly improve the glucose tolerance and gavage starch tolerance in db/db mice(P〈 0. 05). These results suggest that TFC could improve diabetes-related symptoms via regulating glucose and lipids metabolism.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2016年第3期337-341,共5页
Journal of China Pharmaceutical University