摘要
哺乳动物生殖系统的各项功能依赖于下丘脑-垂体-性腺(HPG)轴的调控,是多种因子参与的复杂的生物学过程。RFRP-3是目前下丘脑中唯一已知的HPG轴抑制因子。近年来大量研究发现,RFRP-3能与其受体GPR147结合,抑制促性腺激素释放激素、促黄体生成素的合成与分泌,进而影响生殖系统的功能。本文总结近十年有关哺乳动物RFRP-3/GPR147信号通路的研究,并系统阐述RFRP-3对HPG轴的可能调控机制以及其在生殖系统中的作用。
The function of mammalian reproductive system, a complex biological process involving multiple regulators, depends on the regulation of hypothalamic-pituitary-gonad axis. At present, RFRP-3 is the only one inhibitor of HPG axis known at the hypothalamic level in mammals. In recent years, a large number of studies have found that RFRP-3 can inhibit GnRH and LH release in mammals by combining into the G protein coupled receptor 147（GPR147） and affect the function of reproductive system. In this review, the authors summarize the significant research advances in RFRP/GPR147 signaling pathway in mammalian species in the recent ten years. In addition, the regulatory mechanism of RFRP-3 in HPG axis and role of RFRP-3 in modulating mammalian reproductive system are systematically elaborated.
出处
《中国中西医结合儿科学》
2016年第3期253-257,244,共5页
Chinese Pediatrics of Integrated Traditional and Western Medicine
