地佐辛复合罗哌卡因用于产妇硬膜外全产程分娩镇痛的疗效和安全性观察

Safety and efficacy of Dezocine combined with Ropivacaine for maternal epidural labor analgesia during all stages

目的探讨地佐辛复合罗哌卡因用于产妇硬膜外全产程分娩镇痛的疗效和安全性。方法选取我院2014年6月-2015年10月接诊的300例自然分娩的年轻产妇,ASA分级为Ⅰ-Ⅱ级。根据产妇的意愿将其分成观察组和对照组,每组150例。观察组的产妇给予罗哌卡因结合地佐辛药物进行分娩镇痛,对照组的产妇给予地佐辛药物进行分娩镇痛。对两组产妇的产程时间、疼痛程度、剖宫产率、使用缩宫素的情况、器械助产的情况、新生儿Apgar的评分情况及产妇产后的不良反应发生率进行统计。结果观察组产妇的产程时间明显短于对照组（P〈0.05）;观察组产妇在术后8 h时的疼痛程度显著低于对照组（P〈0.05）;观察组产妇的剖宫产率显著低于对照组（P〈0.05）;观察组产妇使用缩宫素的情况、器械助产的情况以及新生儿Apgar的评分情况与对照组比较,差异无统计学意义（P〉0.05）;两组产妇产后不良反应发生率比较,差异无统计学意义（P〉0.05）。结论地佐辛复合罗哌卡因用于产妇硬膜外全产程分娩镇痛具有较好的临床效果,显著缩短了产妇的产程时间,降低了剖宫产率,提高了产妇的安全性,值得在临床上推广应用。

Objective To explore Dezocine combined with Ropivacaine in the efficacy and safety of maternal epidural labor analgesia during all stages. Methods Our hospital from June 2014 to October 2015 admissions of 300 cases of natural childbirth young mothers,with classification for Ⅰ- Ⅱ level by ASA.In accordance to their will,the childbirth young mothers were randomly divided into observation group and control group,150 cases in each group.The observation group patients were treated with Ropivacaine combined with Dezocine analgesia drugs.The control group patients were given Dezocine in drug delivery analgesia.The duration of labor,maternal pain,section palace yield,maternal use oxytocin,instrumental delivery and neonatal Apgar score and post natal maternal adverse reaction of the two groups childbirth young mothers were incidence statistics and analysis. Results The duration of labor in the observation group was significantly shorter than that in the control group（P〈0.05）.The pain degree after 8 h of the observation group was significantly lower than that of the control group（P〈0.05）.The rate of cesarean section in observation group was significantly lower than that of control group（P〈0.05）.In the observation group,maternal use of oxytocin,instrumental delivery and neonatal Apgar score with that of the control group had no significant difference（P〉0.05）.There was no significant difference in the incidence of adverse reactions between the two groups childbirth young mothers（P〉0.05）. Conclusion Dezocine combined with Ropivacaine for maternal epidural labor analgesia during all stages has a good clinical effect,and significant relationship maternal labor time and cesarean section rate,increase the rate of maternal safety,and it is worth popularizing in clinic.