多西环素联合克林霉素治疗女性生殖道支原体感染的临床疗效和安全性

Clinical efficacy and safety evaluation of doxycycline joint clindamycin for Mycoplasma infection of female genital tract

目的研究多西环素联合克林霉素治疗女性生殖道支原体感染的临床疗效及安全性。方法选择2013年1月-2014年10月本院妇科收治的生殖道支原体感染患者129例为研究对象,依据治疗方法将其分为治疗组与对照组。治疗组采用多西环素口服联合克林霉素静点治疗;对照组采用单一多西环素口服治疗。观察两组治疗效果,评价其安全性。结果治疗组总有效率为96.92%,高于对照组的79.69%,差异有统计学意义（P〈0.05）。治疗组不良反应发生率为15.38%,与对照组的14.06%比较,差异无统计学意义（P〉0.05）。结论多西环素联合克林霉素治疗女性生殖道支原体感染有较好的临床疗效及安全性。

Objective To investigate the clinical efficacy and safety evaluation of doxycycline joint clindamycin for Mycoplasma infection of female genital tract. Methods 129 cases with Mycoplasma infection of female genital tract were divided into treatment group（65 cases） and control group（64 cases） by different treatments in our hospital department of gynaeology from January 2013 to October 2014.The treatment group were given doxycycline by oral joint clindamycin by intrarenous,while the control group were given doxycycline alone.Curative effect of two groups were observed and safety were evaluated. Results The total effective rate was 96.92% in the treatment group,higher than 79.69% in the control group,the difference between the two groups was statistically significant（P〈0.05）.The adverse events occurred in patients of the treatment group was 15.38%,compared with 14.06% in the control group,the difference between the two groups was not statistically significant（P〈0.05）. Conclusion For Mycoplasma infection of female genital tract,the treatment of doxycycline joint clindamycin has a better clinical efficacy and safety.