胺碘酮与利多卡因治疗急性心肌梗死合并室性心律失常的效果比较

Comparison efficacy of amiodarone and lidocaine in the treatment of acute myocardial infarction combined with ventricular arrhythmia

目的分析胺碘酮与利多卡因对急性心肌梗死合并室性心律失常患者的疗效。方法选取2013年3月-2015年3月在我院进行治疗的120例急性心肌梗死合并室性心律失常的患者作为研究对象,采用随机数字表法将其分为胺碘酮组和利多卡因组。利多卡因组患者接受利多卡因静脉注射治疗;胺碘酮组患者接受胺碘酮治疗。比较两组患者经过不同药物治疗后的临床疗效及不良反应发生情况。结果治疗后,胺碘酮组临床总有效率（93.33%）显著高于利多卡因组（68.33%）,差异有统计学意义（P〈0.05）;胺碘酮组患者病死率（3.33%）低于利多卡因组（8.33%）,胺碘酮组治疗过程中发生中枢及心血管不良反应发生率（16.67%）与利多卡因组（6.67%）比较,差异无统计学意义（P〉0.05）。结论对急性心肌梗死合并室性心律失常患者分别给予胺碘酮及利多卡因进行治疗后,胺碘酮临床疗效显著,不良反应少。

Objective To analyze the efficacy of amiodarone and lidocaine in patients with acute myocardial infarction（AMI） combined with ventricular arrhythmia. Methods From March 2013 to March 2015,120 patients with AMI and ventricular arrhythmia treated in our hospital were selected as research objects.They were divided by a random number table.In lidocaine group,lidocaine via intravenous injection was used,while in amiodarone group,patients were treated with amiodarone.The clinical effect and occurrence of adverse reactions after different medications between the two groups were compared. Results After different medications,the total effective rate in the amiodarone group was 93.33%,much higher than that in the lidocaine group accounting for 68.33%,with a statistical difference（P〈0.05）.In the amiodarone group,the fatality rate was 3.33% lower than that in the lidocaine group accounting for 8.33%.The incidence of adverse reactions in center,intra and extra-heart blood vessels in the process of intravenous dripping of amiodarone was16.67%,while in the lidocaine group,the incidence of adverse reactions was 6.67% with non-obvious difference,which was not displayed a statistical significance（P 0.05）. Conclusion For patients with AMI and ventricular arrhythmia,amiodarone and lidocaine are provided separately for treatment,and clinical efficacy is remarkable after using amiodarone with few adverse reactions.