注射用神经生长因子治疗周围神经病变的临床研究

Clinical Study on Injectable Nerve Growth Factor in Treatment of Peripheral Neuropathy

目的研究注射用神经生长因子治疗周围神经病变的临床疗效。方法选取2013年2月至2014年2月入住我院的周围神经损伤患者60例为研究对象,随机分成试验组与对照组各30例。对照组给予常规治疗,试验组在此基础上给予注射用鼠神经生长因子治疗。比较两组的临床治疗效果、神经传导速度变化情况。结果试验组的治疗总有效率为96.67%,显著高于对照组的70.00%,差异具有统计学意义(P<0.05)。治疗后,两组运动神经传导速度(MNCV)和感觉神经传导速度(SNCV)均显著升高,且试验组神经传导速度改善程度显著优于对照组,差异具有统计学意义(P<0.05)。两组不良反应发生率比较无显著差异(P>0.05)。结论神经生长因子具有加速周围神经修复再生、提高周围神经损伤治疗总体疗效的作用。

Objective To study the clinical effect of injectable nerve growth factor （NGF） in treatment of peripheral neuropathy. Methods 60 cases of patients with peripheral nerve injury admitted to our hospital from February 2013 to February 2014 were selected and randomly divided into experimental group and control group, with 30 cases in each group. The control group was given conventional therapy, the experimental group was treated with injectable nerve growth factor on this basis. The clinical effect and changes of nerve conductive velocity were compared between two groups. Results The total effective rate of experimental group was 96.67%, significantly higher than 70.00% of control group, with statistical difference （P〈0.05）. After treatment, the motor nerve conduction velocity （MNCV） and sensory nerve conduction velocity （SNCV） of two groups increased significantly, and the improvement degree of experimental group was better than that of control group, with statistical difference （P 〈0.05）. The incidence of adverse reactions in two groups had no statistical difference （P 〉0.05）. Conclusions Nerve growth factor has the advantages of accelerating the repair and regeneration of peripheral nerve, improving the overall treatment effect of peripheral nerve injury.