甲氰米胍、干扰素联合补锌治疗小儿轮状病毒感染性腹泻疗效观察

Effect observation of cimetidine and interferon combined with zinc supplements in the treatment of children with rotavirus diarrhea

目的:探讨甲氰米胍、干扰素联合补锌治疗小儿轮状病毒感染性腹泻的疗效.方法:选择取内蒙古医科大学附属医院2015-01/2015-12收治的120例轮状病毒感染性腹泻患儿,按照随机数字表法分为观察组(n=60)和对照组(n=60).两组患儿均接受常规对症治疗,在此基础上,对照组给予甲氰米胍联合干扰素治疗,观察组在对照组基础上加用葡萄糖酸锌口服液,观察两组治疗效果.结果:观察组和对照组的总有效率分别为96.7%和75.0%,观察组的总有效率高于对照组,组间比较,差异具有统计学意义(P<0.05);观察组病毒转阴率为63.3%,对照组病毒转阴率为51.7%,观察组病毒转阴率明显高于对照组,差异具有统计学意义(P<0.05);观察组平均住院时间较对照组明显缩短,差异具有统计学意义(P<0.05);观察组体温恢复时间、纠正脱水时间以及大便恢复正常时间均较对照组明显缩短,差异具有统计学意义(P<0.05);观察组和对照组的不良反应发生率分别为13.3%和8.3%,均在停药后自行恢复,不良反应发生率组间比较,差异不显著无统计学意义,(P>0.05).结论:甲氰米胍、干扰素联合补锌治疗小儿轮状病毒感染性腹泻可提高治疗有效率,缩短病程,效果满意.

AIM： To investigate the effect of cimetidine and interferon combined with zinc supplements in the treatment of children with rotavirus diarrhea. METHODS： A total of 120 children with rotavirus diarrhea admitted into Affiliated Hospital of Inner Mongolia Medical University from January 2015 to December2015 were randomly divided into observation group and control group,with 60 cases in each group. Two groups of children were all given conventional symptomatic treatment. In addition,on the basis of this, the control group was treated with cimetidine combined with interferon treatment,while the observation group on the basis of the control group was treated with additional zinc gluconate oral liquid. The effects of the two groups were observed.RESULTS： The total effective rate in the observation group（ 96.7%） was higher than that of the control group（ 75%）,and the difference was statistically significant（ P〈0.05）; Rotavirus in the observation group became negative more quickly than the control group. The observation group virus negative rate was63.3%,while the control group virus negative rate was 51. 7%,and the difference was statistically significant（ P〈0. 05）; The average hospital stay time of the observation group was significantly shorter than the control group,with a statistically significant difference between the two groups（ P〈0.05）; The body temperature recovery time,correct dehydration correction time and stool recovery time in the observation group were significantly shorter than the control group,and there was statistically significant difference between the two groups（ P〈0.05）; The adverse reactions of observation group and control group were 13. 3% and 8. 3%respectively,then recovered after stopping the drug. There was no statistically significant difference in the incidence of adverse reactions between the two groups（ P〉0. 05）. CONCLUSION：Cimetidine and interferon combined with zinc supplements in the treatment of children with rotavirus diarrhea provides satisfactory effect,with a shorter course of disease.