Survivin和COX-2蛋白的异常表达与壶腹癌的临床病理特征及预后的关系

Relationship between the clinicopathological features and prognosis of ampullary carcinoma and abnormal expression of Survivin and COX-2 protein

目的 :探讨Survivin、环氧化酶-2(COX-2)蛋白在壶腹癌组织中的表达变化及其与壶腹癌患者的临床病理特征、预后的关系。方法:以53例壶腹癌患者作为病例组,对其术后组织标本进行免疫组织化学检测,同时选取因交通事故等创伤死亡患者壶腹组织20例作为对照组,对两组壶腹组织中的Survivin、COX-2蛋白表达情况进行比较,并分析其与病理特征、预后的关系。结果:病例组患者壶腹组织中的Survivin蛋白表达阳性率79.25%、COX-2蛋白表达阳性率67.92%,均显著高于对照组的5.00%、10.00%,且差异均具有统计学意义(P<0.05)。壶腹癌组织中Survivin蛋白高表达主要与患者的TNM分期、分化程度具有相关性(P<0.05)。壶腹癌组织中COX-2蛋白高表达主要与患者的TNM分期、分化程度、发生淋巴结转移具有相关性(P<0.05)。壶腹癌组织中COX-2、Survivin蛋白阳性表达对患者的3年随访中位生存时间影响不显著(P>0.05)。结论:壶腹癌组织中Survivin、COX-2蛋白显著高表达,并且与患者的TNM分期、分化程度、淋巴结转移具有一定的关系,但是与患者的远期预后关系尚不明确。

Objective： To investigate the expression of Survivin and cyclooxygenase-2 （COX-2） protein in carcinoma of the ampulla of Vater expression changes of patients with carcinoma of ampulla of Vater and clinicopathological features and prognosis. Methods： In 53 cases of ampullary cancer patients as the case group were detected by immunohistochemistry after their tissues, while select patients who died due to traffic accidents and other trauma ampulla organization 20 cases as the control group, two groups ampullary tissue Survivin , COX-2 protein expression were compared and analyzed with pathological features, prognosis. Results： Ampulla tissue of patients in the case group Survivin protein positive rate of 79.25%, COX-2 protein expression positive rate of 67.92%, significantly higher than the 5.00%, 10.00%, and the differences were statistically significant（P〈 0.05 ）. Survivin protein expression in carcinoma and TNM stage major, degree of differentiation correlated（P〈 0.05）. High expression of COX-2 protein in carcinoma and staging major, degree of differentiation TNM patients, lymph node metastasis correlated（P〈 0.05）. Carcinoma of the COX-2, Survivin protein expression in patients 3 years of follow-up, the median survival time no significant effect（P〉 0.05）. Conclusion： In carcinoma Survivin, COX-2 protein expression was significantly higher, and with TNM stage, degree of differentiation, lymph node metastasis have a certain rela- tionship, but the relationship with the patient＇s long-term prognosis is not clear.